7274-93-3Relevant academic research and scientific papers
Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors
Shehzad, Muhammad Tariq,Imran, Aqeel,Hameed, Abdul,Rashida, Mariya al,Bibi, Marium,Uroos, Maliha,Asari, Asnuzilawati,Iftikhar, Shafia,Mohamad, Habsah,Tahir, Muhammad Nawaz,Shafiq, Zahid,Iqbal, Jamshed
, p. 17259 - 17282 (2021)
Inhibition of aldose reductase (ALR2) by using small heterocyclic compounds provides a viable approach for the development of new antidiabetic agents. With our ongoing interest towards aldose reductase (ALR2) inhibition, we have synthesized and screened a
Synthesis, characterization and anti-tubercular activity of substituted thiosemicarbazones and their ni(ii) complexes
Ul Ain, Qurat,Insha, Sheikh,Sharma, Rekha
, p. 3208 - 3214 (2021/05/26)
Complexes of substituted isatin-3-thiosemicarbazones (H2itsc-N1-Me, H1L; H2itsc-N1-Ph, H2L) and substituted indole-3-thiosemicarbazone (HIntsc-N1-Ph, H3L) with Ni (II) and triphenylphoshine of formula, [NiCl(L)(Ph3P)] (anionic form of L = 1L, 1; 2L, 2, 3L, 3) have been synthesized. The ligands and complexes have been characterized using spectroscopic techniques (IR, 1H NMR). 1HNMR of complexes supports binding of thio- ligands in anionic form. All the ligands (H1L - H3L) and their complexes were evaluated for their antitubercular activities. The enhancement in anti-TB activity of ligands on complexation with Ni(II) has been observed.
A thiourea structure unit including shrinking amino aromatic compound and its preparation method and application (by machine translation)
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Paragraph 0119; 0124-0127, (2019/07/10)
The invention relates to the technical field of pharmaceutical chemistry, and in particular relates to a thiourea structure unit including shrinking amino aromatic compound and its preparation method and application. The present invention provides including shrinking amino thiourea structure unit of the aromatic heterocyclic compound with the gastric cancer cells through the inner metal ion chelating form stable complexes, thereby suppressing the MGC803 gastric cancer cell proliferation activity. The results of the embodiment of the display, and the compound 3 - AP compared with, the present invention provides including shrinking amino thiourea structure unit of the aromatic heterocyclic compound to stomach MGC803 has better proliferation inhibitory activity. (by machine translation)
Photochromic behavior and mechanism of indole thiosemicarbazide derivates in amorphous powder, solution and nanofiber
Che, Yuanyuan,Liu, Lang,Zhao, Jianzhang,Yu, Yuming,Zhao, Xianmei
, p. 105 - 110 (2019/05/27)
A series of Schiff bases containing the indole group were synthesized. The compound 2-[(1-methyl-1H-indol-3-yl)methylene] hydrazinecarbothioamide (4) exhibits excellent reversible photochromic properties both in solid?solid state and solution. Moreover, t
Solvent-free synthesis of indole-based thiosemicarbazones under microwave irradiation
Liu, Lingling,Yang, Jie,Zhao, Zhigang,Shi, Peiyu,Liu, Xingli
experimental part, p. 57 - 60 (2010/05/19)
A rapid, effi cient and environmentally friendly methodology has been developed for the synthesis of indole-3-carboxaldehyde thiosemicarbazones by using aluminum oxide as the solid support under microwave assisted solvent-free conditions. Compared with the conventional heating method, this method gave the target products in good yield.
