72740-36-4Relevant academic research and scientific papers
An improved synthesis of β-carboline and azepino-and azocino[3,4-b]indole derivatives from lactams
Tokmakov
, p. 211 - 216 (2014/06/23)
The Vilsmeier formylation of butyrolactam, N-methylbutyrolactam, N-methylvalerolactam, and N-methylcaprolactam followed by treatment with aryl hydrazines afforded the 2,3,4,9-tetrahydro-1H-β-carbolin-1-ones, 3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-ones, and 2,3,4,5,6,11-hexahydro- 1H-azocino[3,4-b]indol-1-ones. The synthesis was performed as a one-pot process without isolating the intermediate a-formyl lactams.
An improved synthesis of β-carboline and azepino- and azocino[3,4-b]indole derivatives from lactams
Tokmakov
, p. 211 - 216 (2015/09/28)
The Vilsmeier formylation of butyrolactam, N-methylbutyrolactam, N-methylvalerolactam, and N-methylcaprolactam followed by treatment with aryl hydrazines afforded the 2,3,4,9-tetrahydro-1H-β-carbolin-1-ones,3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-ones, and 2,3,4,5,6,11-hexahydro-1H-azocino[3,4-b]indol-1-ones. The synthesis was performed as a one-pot process without isolating the intermediate α-formyl lactams.
