72740-55-7

Upstream product

• 3855-24-1 cyclohexane-1,1-dithiol 
• 39145-33-0 2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide 
• 70-11-1 α-bromoacetophenone 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 41381-89-9 2-(4-phenylthiazol-2-yl)acetonitrile 
• 72740-51-3 2-Amino-4-(4-chloro-phenyl)-1,5-dithia-spiro[5.5]undec-2-ene-3-carbonitrile 
• 83236-47-9 7-Amino-9-(4-chloro-phenyl)-6,10-dithia-spiro[4.5]dec-7-ene-8-carbonitrile 

Downstream Products

• 277308-35-7 4-(4-chloro-phenyl)-2,5-diphenyl-3-(4-phenyl-thiazol-2-yl)-3,4-dihydro-2H-pyrazole-3-carbonitrile 

Relevant academic research and scientific papers

Design and synthesis of disubstituted and trisubstituted thiazoles as multifunctional fluorophores with large Stokes shifts

A series of fluorophores based on a thiazole core have been synthesized and shown to be very sensitive to both structural changes and the microenvironment. Simple modifications of the substituents’ electronic nature, spatial effects and location in the mo

Reactions with hydrazonoyl halides XIX1: Synthesis of some pyrazole and 5-arylazothiazole derivatives

Hydrazonoyl chlorides 1 reacted with 2-aryl-1-cyano-1-thiazol-2-ylethenes 2 in presence of triethylamine to give the cycloadducts 4. which were converted to the corresponding pyrazoles 5 by the action of sodium methoxide. The reaction of hydrazonoyl halides 1 and 6 with each of 2-arylidene-2-cyanoethanethioamides 7 and 2-arylhydrazono-2-cyanoethanethioamides 14 in ethanolic triethylamine or ethanolic sodium hydroxide solutions, has been investigated. Structures of all the products were established on the basis of their spectral data and alternative synthesis.

Reactions with Hydrazonoyl Halides. Part 10. Formation of Thiohydrazide, Hydrazonoyl Sulfide and Arylazothiazole Derivatives

Hydrazonoyl halides react with α-thiocarbamoylcinnamonitrile derivatives, under alkaline conditions, to afford thiohydrazide (4), hydrazonoyl sulfide (7a,b) or arylazothiazole derivatives (9a,b), depending on the nature of the hydrazonoyl halide; a sequence leading to the formation of these products is discussed.

CYCLIZATION OF NITRILES. X. ENAMINO NITRILES OF THE 1,3-DITHIA-4-CYCLOHEXENE SERIES AND THEIR RECYCLIZATION TO DERIVATIVES OF PYRIDINE AND THIAZOLE

The recyclization of 4-amino-6-aryl-5-cyano-2-cyclopentane(cyclohexane)spiro-1,3-dithia-4-cyclohexenes, obtained from gem-dithiols and arylidenemalononitriles, leads to the formation of 4-aryl-5,6-polymethylene-3-cyano-2-(1H)-pyridinethiones.The latter are used in the synthesis of various 3-aminothienopyridines, 4-aryl-3-amino-5,6,7,8-tetrahydrothienoquinolines, and other heterocyclic compounds condensed with quinoline. 1-Cyano-1-(4-aryl-2-thiazolyl)-2-arylethylenes were obtained by the reaction of the 1,3-dithia-4-cyclohexenes with phenacyl bromides.