727401-24-3

Usage

Main properties

Synthetic cathinone
Central nervous system stimulant
Belongs to the class of substituted cathinones

Also known as

4'-chloro-α-pyrrolidinopentiophenone (4'-Cl-α-PVP) or hydrochloride
Derivative of α-pyrrolidinopentiophenone (α-PVP)
Associated with side effects such as agitation, aggression, paranoia, and hallucinations
Linked to cases of overdose and fatalities
Classified as a controlled substance in many countries
Abuse potential and adverse effects pose concerns for public health and law enforcement officials

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 1670-46-8 2-acetylcyclopentanaone 

Relevant academic research and scientific papers

Graphene oxide catalyzed ketone α-alkylation with alkenes: Enhancement of graphene oxide activity by hydrogen bonding

Direct α-alkylation of carbonyl compounds represents a fundamental bond forming transformation in organic synthesis. We report the first ketone-alkylation using olefins and alcohols as simple alkylating agents catalyzed by graphene oxide. Extensive studies of the graphene surface suggest a pathway involving dual activation of both coupling partners. Notably, we show that polar functional groups have a stabilizing effect on the GO surface, which results in a net enhancement of the catalytic activity. The method represents the first alkylation of carbonyl compounds using graphenes, which opens the door for the development of an array of protocols for ketone functionalization employing common carbonyl building blocks and readily available graphenes.

Bronsted acid mediated heterogeneous addition reaction of 1,3-dicarbonyl compounds to alkenes and alcohols

(Chemical Equation Presented) The unique acidity of a proton-exchanged montmorillonite catalyst (H-mont) was exploited in the nucleophilic addition of 1,3-dicarbonyl compounds to simple alkenes (see scheme). The benzylation and allylation of 1,3-dicarbony

Highly efficient, reversible addition of activated methylene compounds to styrene derivatives catalyzed by silver catalysts

A highly efficient inter- and intramolecular addition of 1,3-diketone/β-ketoester to alkenes was developed by using silver catalysts. Silver triflate shows the highest catalytic activity. The reaction is reversible through the cleavage of a carbon-carbon bond by silver at an elevated temperature.

Highly efficient addition of activated methylene compounds to alkenes catalyzed by gold and silver

A highly efficient intermolecular addition of 1,3-diketones to alkenes catalyzed by AuCl3/AgOTf was developed. A mechanistic rationale for the reaction has been proposed via a α-C-H activation. Copyright