727428-59-3Relevant academic research and scientific papers
Synthesis, biological activity, and QSAR studies of antimicrobial agents containing biguanide isosteres
Wernert, Gregory T.,Winkler, David A.,Holan, George,Nicoletti, Gina
, p. 77 - 85 (2004)
Analogues of chlorhexidine and chemically related antimicrobial compounds were synthesized, based on a model in which the bisbiguanide moieties were replaced by conformationally restricted cyclic isosteres. This model was tested by measuring the antimicro
Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents
Kim, Woochan,Kang, Jung-Ah,Park, Minji,Jeong, Pyeong-Hwa,Kim, Yoon Jun,Cho, Yuri,Park, Sung-Gyoo,Kim, Yong-Chul
, p. 5500 - 5518 (2021/05/31)
Core assembly modulators of viral capsid proteins have been developed as an effective treatment of chronic hepatitis B virus (HBV) infection. In this study, we synthesized novel potent pyrimidine derivatives as core assembly modulators, and their antivira
