7275-70-9

Usage

InChI:InChI=1/C6H9N3S/c1-4-5(2)8-9-6(7-4)10-3/h1-3H3

Upstream product

• 431-03-8 dimethylglyoxal 
• 35600-34-1 S-methylisothiosemicarbazide hydroiodide 
• 35600-34-1 S-methyl isothiosemicarbazide hydroiodide 

Downstream Products

• 84437-48-9 6,7-Dimethyl-4-methylsulfanyl-2-phenyl-pyrrolo[3,4-c]pyridine-1,3-dione 
• 69466-56-4 3-allyloxy-5,6-dimethyl-1,2,4-triazine 
• 28735-31-1 5,6-dimethyl-3-methoxy-1,2,4-triazine 
• 69466-66-6 3-Isopropoxy-5,6-dimethyl-1,2,4-triazin 
• 105783-88-8 5,6-dimethylfuro<2,3-b>pyridine 
• 105783-85-5 2,3-dihydro-5,6-dimethylfuro<2,3-b>pyridine 

Relevant academic research and scientific papers

Organocatalyzed Thia-Michael Addition and Sequential Inverse Electron Demanding Diels-Alder Reaction to 3-Vinyl-1,2,4- triazine Platforms

This work highlights the use of 3-vinyl-1,2,4-triazines as original thia-Michael acceptors and inverse electron demanding Diels-Alder platforms en route to new 7,8-dihydro-5H-thiopyrano[4,3-b]pyridines. The required but rather unstable propargylthiol nucleophiles were successfully generated in-situ upon an innovative DBU-catalyzed methanolysis event of the corresponding propargyl thioacetate derivatives. (Figure presented.).

Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines

A straightforward domino aza-Michael-inverse-electron-demand-hetero-Diels-Alder/retro-Diels-Alder reaction between primary and secondary propargylamine derivatives and 3-vinyl-1,2,4-triazines is developed highlighting not only the uniqueness of this dual-

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge

FURTHER INTRAMOLECULAR DIELS-ALDER REACTIONS OF 1,2,4-TRIAZINES. SYNTHESIS OF DIHYDROPYRROLOpyridines

3-(3-Butynylamino)-1,2,4-triazines undergo intramolecular Diels-Alder reactions to yield 2,3-dihydropyrrolopyridines

FURTHER INTRAMOLECULAR REACTIONS OF 1,2,4-TRIAZINES. SYNTHESIS OF FUROPYRIDINES AND DIHYDROPYRANOPYRIDINES

3-(3-Butynyloxy)- and 3-(4-pentynyloxy)-1,2,4-triazines undergo facile intramolecular Diels-Alder reactions to yield 2,3-dihydrofuro(2,3-b)pyridines and dihydropyrano(2,3-b)-pyridines respectively.The former are readily dehydrogenated with DDQ to furo(2,3

Synthesis and anti-inflammatory evaluation of 3-methylthio-1,2,4-triazines, 3-alkoxy-1,2,4-triazines, and 3-aryloxy-1,2,4-triazines

To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice. 25 Compounds possessed activity comparable to the standard, indomethacin. Thirteen of the 25 compounds were selected for dose-response evaluation in the carrageenan assay based on their relative toxicity and anti-inflammatory activity. Neurotoxicity of the 13 triazines was estimated by determination of NTD50 values in mice. Five of the 13 compounds tested in the dose-response assay were active in terms of anti-inflammatory efficacy (ED50 values) and lack of overt neurotoxicity (NTD50 values) when compared to indomethacin. To determine the effect of these five developmental triazines on chronic inflammation, they were evaluated in the adjuvant-induced polyarthritis assay. One was comparable to indomethacin in reducing adjuvant-induced inflammation in this assay.

Pharmacologically active substituted 1,2,4-triazines

Substituted 1,2,4-triazines, compositions thereof and methods of using same are described. The compounds of the invention exhibit a wide range of pharmacological activity including anti-inflammatory, analgesic, anti-pyretic, hypotensive and central nervous system effects.