727705-49-9Relevant academic research and scientific papers
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist
Becker, Daniel P.,Flynn, Daniel L.,Villamil, Clara I.
, p. 3073 - 3075 (2007/10/03)
Pyrrolizidine benzamide (±)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (±)-2 has an EC50 of 449nM in the TMM assay, as compared to 23nM for SC-53116, and 66nM for the racemate of SC-53116.
