72774-33-5Relevant academic research and scientific papers
Qualitative and quantitative contributions of intermolecular interactions of dinuclear Ag complexes of sulfathiazole and sulfadiazine: X-ray crystallographic, Hirshfeld surface analysis, DFT studies and biological activities
Alalawy, Mohammed Dawood,Bhatt, Bhupesh S.,Dhaduk, Milan P.,Patel, R. H.,Patel, Urmila H.,Socha, Bhavesh N.
, (2022/01/27)
Two dinuclear Ag complexes of N-heterocycle ‘sulfa’ derivatives: sulfathiazole (STZ) and sulfadiazine (SDZ) have been synthesized and characterized. Crystal structures of both the Ag-STZ and Ag-SDZ complexes have been determined by single crystal X-ray diffraction technique. In both the dinuclear Ag complex, two Ag atoms bridged together forming argentophilic interaction with Ag – Ag separation distance of 2.846 (4) ? in Ag-STZ and 2.828 (3) ? in Ag-SDZ respectively. In Ag-STZ complex, the coordination geometry surrounding silver atoms (Ag) is tridentate and tetradentate whereas, in Ag-SDZ complex, the geometry surrounding Ag is tetradentate and pentadentate respectively while coordinating to the respective bidentate ligand. Qualitative and quantitative contributions of each intermolecular interaction as established by X-ray data are investigated using Hirshfeld surface and energy framework analysis. Atomic charge explored by Mulliken charge distributions and natural bond orbital (NBO) analysis confirmed the nature and type of intermolecular interactions as established by X-ray data. In vitro cytotoxicity of the Ag complexes and those of the free ligands have been carried out against brine shrimp.
Silver complexes with sulfathiazole and sulfamethoxazole: Synthesis, spectroscopic characterization, crystal structure and antibacterial assays This work is dedicated to Professor Antonio Carlos Massabni in the occasion of his 70th anniversary.
Bormio Nunes, Julia Helena,De Paiva, Raphael Enoque Ferraz,Cuin, Alexandre,Lustri, Wilton Rogrio,Corbi, Pedro Paulo
, p. 437 - 444 (2015/02/19)
The present work describes the synthesis and spectroscopic characterization of two silver(I) complexes with the sulfonamides sulfathiazole (AgC9H8N3O2S2, Ag-SFT) and sulfamethoxazole (AgC10H10N3O3S, Ag-SFM). Elemental analyses indicate a 1:1 metal/ligand composition for both complexes. Spectroscopic techniques such as 1H, 15N NMR and IR evidence the coordination of both ligands to silver through the nitrogen atom of the sulfonamide group, and also indicate the participation of the 5-membered N-heterocyclic ring in the coordination. The Ag-SFT crystal structure was solved by X-ray powder diffraction and indicates the formation of a dimeric structure with silver bridging between two ligand molecules. Biological studies showed the antibacterial activity of Ag-SFT and Ag-SFM complexes against Gram-positive and Gram-negative bacterial strains, with MIC values ranging from 3.45 to 6.90 mmol L-1 for the sulfathiazole complex and 1.74 to 13.9 mmol L-1 for the sulfamethoxazole complex. The complexes have shown to be more active against Gram-negative bacterial strains.
