72776-12-6

Upstream product

• 4124-41-8 p-toluenesulfonylanhydride 
• 72776-13-7 (R)-3-Hydroxy-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 93552-86-4 (R)-3,8-Dioxo-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid tert-butyl ester 
• 74627-99-9 4(R)-4-[3-oxo-4-diazo-4-(t-butyloxycarbonyl)butyl]-azetidin-2-one 
• 93552-82-0 5-[(R)-1-(tert-Butyl-dimethyl-silanyl)-4-oxo-azetidin-2-yl]-2-[1-dimethylamino-meth-(Z)-ylidene]-3-oxo-pentanoic acid tert-butyl ester 
• 93552-83-1 5-[(R)-1-(tert-Butyl-dimethyl-silanyl)-4-oxo-azetidin-2-yl]-2,3-dioxo-pentanoic acid tert-butyl ester 
• 93552-81-9 5-[(R)-1-(tert-Butyl-dimethyl-silanyl)-4-oxo-azetidin-2-yl]-3-oxo-pentanoic acid tert-butyl ester 
• 79262-24-1 4(R)-4-[4-(t-butyloxycarbonyl)-3-oxobutyl]-azetidin-2-one 
• 1694-31-1 tert-butyl acetoacetate 
• 93552-84-2 (R)-2-Hydroxy-3,8-dioxo-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid tert-butyl ester 

Downstream Products

• 74645-70-8 (6R,7R)-7-((R)-1-Hydroxy-ethyl)-8-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 74645-69-5 (6R,7S)-7-((S)-1-Hydroxy-ethyl)-8-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 72776-14-8 (6R,7S)-7-((R)-1-Hydroxy-ethyl)-8-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

VICINAL TRICARBONYL PRODUCTS FROM SINGLET OXYGEN REACTIONS. APPLICATION TO THE SYNTHESIS OF CARBACEPHAMS.

Vicinal tricarbonyl systems are readily formed by reacting β-dicarbonyl precursors with DMF acetal to form enamines which are then cleaved by photooxidation.This procedure may be applied to the formation of carbacephams.

Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor

Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediate II: STR1 R=blocking group

4-Iodomethylazetidin-2-one

Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediates II and IIa (4-iodomethylazetidin-2-one): STR1