72782-13-9Relevant articles and documents
Mutagenicity and Chemistry of N-Nitroso-N-(p-substituted-benzyl)methylamines
Singer, George M.,Andrews, A.W.
, p. 309 - 312 (2007/10/02)
The relative mutagenicities of N-nitroso-N-(p-substituted-benzyl)methylamines in Salmonella typhimurium TA 1535 were tested in order to determine whether biological activity is affected by the electron density at a nitrosamine α carbon.The order of potency was as follows: X = Cl > CN > Br > NO2 > H > CH3O > CH3 > F >> COOH.No direct correlation was apparent, nor was there obvious correlation between biological activity and the extent of base-catalysed hydrogen-deuterium exchange at the α-carbons.