72791-83-4Relevant academic research and scientific papers
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: Unique effects of the axial chirality on the selectivity of protein kinases inhibition
Yoshida, Kenyu,Itoyama, Ryosuke,Yamahira, Masashi,Tanaka, Junji,Loa?c, Nadège,Lozach, Olivier,Durieu, Emilie,Fukuda, Tsutomu,Ishibashi, Fumito,Meijer, Laurent,Iwao, Masatomo
supporting information, p. 7289 - 7301 (2013/10/21)
The total synthesis of the optically active (aR)- and (aS)-16- methyllamellarins N (3a and 3b) was achieved via resolution on HPLC chiral stationary phase. The kinase inhibitory activities of both enantiomers were evaluated on eight protein kinases releva
A general synthesis of dihydrobenzofurans by intramolecular conjugate addition
Weeratunga, Gamini,Jaworska-Sobiesiak, Alina,Horne, Stephen,Rodrigo, Russel
, p. 2019 - 2023 (2007/10/02)
ortho Iodophenoxy crotonates 3e-7e cyclize to dihydrobenzofurans 1 and 9-12 when subjected to lithium-iodine exchange at -100 deg C.Naphtofuran 13 can be similarly obtained from α-iodonaphtoxy crotonate 8e.Methylation of this reaction mixture in
