728-88-1 Hazards Identification
Pictogram(s):
Signal:
Warning
GHS Hazard Statements:
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H320 (100%): Causes eye irritation [Warning Serious eye damage/eye irritation]
H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H401 (100%): Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]
Precautionary Statement Codes:
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, and P501
Hazard Classes and Categories:
Acute Tox. 4 (100%)
Eye Irrit. 2B (100%)
Aquatic Acute 2 (100%)
728-88-1 Usage
Brand name
Tolperisone Hydrochloride
is JAN.
Check Digit Verification of cas no
The CAS Registry Mumber 728-88-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 728-88:
(5*7)+(4*2)+(3*8)+(2*8)+(1*8)=91
91 % 10 = 1
So 728-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3
728-88-1Relevant academic research and scientific papers
TOLPERISONE ANALOGS AND METHODS OF USE
-
Page/Page column 28, (2019/10/29)
The present invention is, in part, directed to tolperisone analogs (e.g., compounds of formula (I), (I-a), (I-b), (II), (Il-a), (III), (Ill-a), (ΙΙΙ-b), (III-c), (IV), (IV-a), (V), or (V-a)) and methods of use thereof for the treatment of various conditions including elevated muscle tone and tension (e.g., spasticity, muscle spasm). In one aspect, the tolperisone analogs disclosed herein have an additional substituent at the α-position, which blocks the generation of a β- elimination product.
Synthesis of 3H-tolperisone
Dietrich, Axel,Fels, Gregor
, p. 1125 - 1134 (2007/10/03)
Tolperisone has been tritiated to 50 Ci/mmol specific activity in order to use this compound in the study of muscle relaxant binding. Of the two reaction pathways investigated, hydrogenolytic exchange of aromatic bromine is favored over hydrogenation of a double bond.
