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Basic information

• Product Name: Tolperisone
• Synonyms: AKOS 91983;1-piperidino-2-methyl-3-(p-tolyl)-3-propanone;2,4’-dimethyl-3-piperidino-propiophenon;2-methyl-3-piperidino-1-p-tolylpropan-1-one;mydeton;TOLPERISONE;2'4-Dimethyl-3-PiperidylPropiophenone;1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)- (9CI)
• CAS NO: 728-88-1
• Molecular Formula: C₁₆H₂₃NO
• Molecular Weight: 245.36
• EINECS: 211-976-4
• Mol File: 728-88-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 176.5°C
• Boiling Point: 388.33°C (rough estimate)
• Flash Point: 134.4°C
• Appearance: /
• Density: 0.9672 (rough estimate)
• Vapor Pressure: 8.66E-06mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• PKA: 8.47±0.10(Predicted)
• CAS DataBase Reference: Tolperisone(CAS DataBase Reference)
• NIST Chemistry Reference: Tolperisone(728-88-1)
• EPA Substance Registry System: Tolperisone(728-88-1)

Safety Data

• Hazardous Substances Data: 728-88-1(Hazardous Substances Data)

Usage

Brand name

Tolperisone Hydrochloride is JAN.

InChI:InChI=1/C16H23NO/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17/h6-9,14H,3-5,10-12H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 5337-93-9 4'-methylpropiophenone 
• 75-75-2 methanesulfonic acid 
• 6091-44-7 piperidine hydrochloride 
• 122-00-9 para-methylacetophenone 
• 1023-20-7 3-(piperidin-1-yl)-1-(p-tolyl)propan-1-one hydrochloride 

Downstream Products

• 1043449-71-3 loxoprofen tolperisone salt 

Relevant articles and documents

TOLPERISONE ANALOGS AND METHODS OF USE

The present invention is, in part, directed to tolperisone analogs (e.g., compounds of formula (I), (I-a), (I-b), (II), (Il-a), (III), (Ill-a), (ΙΙΙ-b), (III-c), (IV), (IV-a), (V), or (V-a)) and methods of use thereof for the treatment of various conditions including elevated muscle tone and tension (e.g., spasticity, muscle spasm). In one aspect, the tolperisone analogs disclosed herein have an additional substituent at the α-position, which blocks the generation of a β- elimination product.