72802-34-7Relevant academic research and scientific papers
Antisecretory guanidine derivatives and pharmaceutical compositions containing them
-
, (2008/06/13)
The guanidine derivative has the formula: STR1 where X is O or S: Y is N, CH or CCH3 : m is 0 or 1: R1 is hydrogen and R2 cyano, trifluoroacetyl, C1-6 alkanoyl, 4,5-dihydro-4-oxothiazol-2-yl or A-B where A is 3,4-dioxocyclobutene-1,2-diyl or C=Z where Z is oxygen, sulphur, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR6, NCO2 R6, NSO2 R6 or NR7 where R6 is C1-6 alkyl and R7 is hydrogen or C1-6 alkyl and B is C1-6 alkyl, alkoxy or alkylthio or NR8 R9 where R8 and R9 are hydrogen, C1-10 alkyl, C3-10 -alkenyl, alkynyl or alkoxyalkyl, C2-6 (primary hydroxy)alkyl, or, when R9 is hydrogen, R8 is 2-[[5-dimethylaminomethylfuran-2-yl]methylthio]-ethylamino or R8 and R9 are together a 5- or 6-membered non-aromatic ring optionally containing an additional N or O; or R1 and R2 are together imidazolidin-2-ylidene: R3 is hydrogen or fluorine: R4 is halogen or methyl: R5 is hydrogen, C1-6 alkyl or C3-10 alkoxyalkyl: and the salts thereof.
