728023-20-9Relevant academic research and scientific papers
Defect-engineered porphyrinic metal-organic framework nanoparticles for targeted multimodal cancer phototheranostics
Wang, Chenyuan,Xiong, Chuxiao,Li, Zhike,Hu, Liefeng,Wei, Jianshuang,Tian, Jian
, p. 4035 - 4038 (2021)
Defect-engineered porphyrinic MOF nanoparticles were fabricated with anin situone-pot protocol using cypate as the co-ligand and modulator. This multifunctional nanoplatform integrated the photothermal and multimodal imaging properties of cypate with the photodynamic effects of porphyrins, thus achieving targeted multimodal cancer phototheranostics after folic acid modification.
Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes
Oushiki, Daihi,Kojima, Hirotatsu,Terai, Takuya,Arita, Makoto,Hanaoka, Kenjiro,Urano, Yasuteru,Nagano, Tetsuo
supporting information; experimental part, p. 2795 - 2801 (2010/05/19)
Reactive oxygen species (ROS) operate as signaling molecules under various physiological conditions, and overproduction of ROS is involved in the pathogenesis of many diseases. Therefore, fluorescent probes for visualizing ROS are promising tools with which to uncover the molecular mechanisms of physiological and pathological processes and might also be useful for diagnosis. Here we describe a novel fluorescence probe, FOSCY-1, operating in the physiologically favorable near-infrared region. The probe consists of two differentially ROS-reactive cyanine dyes connected by a linker; reaction of the more susceptible dye with ROS releases intramolecular fluorescence quenching of the less susceptible dye. We successfully applied this probe to detect ROS produced by HL60 cells and porcine neutrophils and for imaging oxidative stress in a mouse model of peritonitis.
