728033-28-1

Basic information

• Product Name: 4-(5-bromo-2-fluorophenyl)-butyric acid
• CAS NO: 728033-28-1
• Molecular Weight: 261.091
• Mol File: 728033-28-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(5-bromo-2-fluorophenyl)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-bromo-2-fluorophenyl)-butyric acid(728033-28-1)
• EPA Substance Registry System: 4-(5-bromo-2-fluorophenyl)-butyric acid(728033-28-1)

Safety Data

• Hazardous Substances Data: 728033-28-1(Hazardous Substances Data)

Upstream product

• 657427-46-8 4-bromo-2-ethynyl-1-fluorobenzene 
• 99725-12-9 4-bromo-2-(bromomethyl)-1-fluorobenzene 

Downstream Products

• 728033-48-5 1-(5-benzyloxy-8-formylnaphthalen-1-yloxy)-5-methoxymethoxynaphthalene-4-carbaldehyde 

Relevant articles and documents

Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to > 100 μM.