728035-42-5

Upstream product

• 74209-25-9 3-bromo-1-methyl-5-nitro-1H-indazole 
• 98-80-6 phenylboronic acid 
• 5401-94-5 5-nitroindazole 
• 5228-49-9 1-methyl-5-nitro-1H-indazole 
• 71-43-2 benzene 
• 591-50-4 iodobenzene 

Downstream Products

• 1620816-81-0 7-(4-methoxyphenyl)-1-methyl-5-nitro-3-phenyl-1H-indazole 
• 1620816-82-1 7-(4-(trifluoromethyl)phenyl)-1-methyl-5-nitro-3-phenyl-1H-indazole 
• 1620816-64-9 1-methyl-5-nitro-3,7-diphenyl-1H-indazole 
• 1620816-83-2 ethyl 4-(1-methyl-5-nitro-3-phenyl-1H-indazol-7-yl)benzoate 
• 1620816-84-3 1-methyl-5-nitro-3-phenyl-7-o-tolyl-1H-indazole 
• 1620816-85-4 1-methyl-5-nitro-3-phenyl-7-m-tolyl-1H-indazole 
• 1620816-73-0 1-methyl-5-nitro-3-phenyl-7-p-tolyl-1H-indazole 

Relevant academic research and scientific papers

Palladium-Catalyzed Oxidative Arylation of 1H-Indazoles with Arenes

A simple method for the direct Pd(OAc)2-catalyzed oxidative arylation of inactivated 1H-indazole derivatives with simple arenes is reported. This method exhibits good reaction efficiency and good functional-group tolerance. Using the developed method, 28 arylated products were prepared in yields up to 80 %.

Palladium-catalyzed direct C7-arylation of substituted indazoles

A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K 2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/ arylation procedure leading to C3,C7-diarylated indazoles has been developed.