72817-97-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-amino-5-cyanosalicylate is used as an intermediate in the synthesis of 4-Amino-6-hydroxy-1,3-benzenedicarboxylic Acid (A634570), a compound with tuberculostatic activity. It is employed for the development of drugs targeting tuberculosis, a significant global health concern.
Additionally, ethyl 4-amino-5-cyanosalicylate is used as an intermediate in the synthesis of compounds with antimalarial activity. Malaria is a life-threatening disease caused by parasites that are transmitted to humans through the bites of infected mosquitoes. The development of drugs using ethyl 4-amino-5-cyanosalicylate can contribute to the fight against malaria, which affects millions of people worldwide.

InChI:InChI=1/C10H10N2O3/c1-2-15-10(14)7-3-6(5-11)8(12)4-9(7)13/h3-4,13H,2,12H2,1H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 123-06-8 Ethoxymethylenemalononitrile 
• 109-77-3 malononitrile 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 49836-24-0 (E)-2-(ethoxymethylene)-3-oxobutanoic acid ethyl ester 

Downstream Products

• 72817-96-0 4-Amino-5-carbamoylsalicylsaeure 

Relevant academic research and scientific papers

PESTICIDALLY ACTIVE CYCLIC AMINE COMPOUNDS

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.

Quinazoline derivative and preparation method and application thereof

The invention relates to a quinazoline derivative and a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The structure of the quinazoline derivative is as shown in a formula I. The quinazoline derivative or a pharmaceutically acceptable salt thereof has an irreversible inhibition effect on tyrosine kinase, the compound can inhibit two kinds of tyrosine kinase of EGFR and HER2 simultaneously, and the compound has good inhibitory activity on multiple cancer cell lines. Please see the formula I in the description.

SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNO-MODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS

The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.

Solid-phase synthesis of 5-biphenyl-2-yl-1h-tetrazoles

(Equation presented) The combinatorial synthesis of novel biphenyl tetrazoles is described. Key steps include the simultaneous biphenyl formation and phenol deallylation under Suzuki cross-coupling conditions as well as the tetrazole ring formation on solid support. A representative library of 20 biphenyl tetrazoles was synthesized.