72822-03-8 Usage
Uses
Used in Pharmaceutical Industry:
Pergolide sulfone is used as an antiparkinsonian agent for the treatment of Parkinson's disease. It helps in managing the symptoms by increasing the levels of dopamine in the brain, which is a neurotransmitter that is often deficient in patients with Parkinson's disease.
Used in Endocrine Regulation:
Pergolide sulfone is used as a regulator of endocrine function due to its ability to decrease plasma prolactin concentrations. High levels of prolactin can lead to various health issues, and pergolide sulfone can help in maintaining a balanced hormonal profile.
Used in Research and Development:
As a metabolite of Pergolide, pergolide sulfone is also used in research and development for studying the effects of dopaminergic agonists on the central nervous system and their potential applications in treating various neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 72822-03-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,8,2 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 72822-03:
(7*7)+(6*2)+(5*8)+(4*2)+(3*2)+(2*0)+(1*3)=118
118 % 10 = 8
So 72822-03-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H26N2O2S/c1-3-7-21-11-13(12-24(2,22)23)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16?,18-/m1/s1
72822-03-8Relevant academic research and scientific papers
Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone
Smith,Davis,Kerr
, p. 733 - 736 (2007/10/02)
Fifty-eight microorganisms were investigated for their ability to effect the biotransformation of the ergoline alkaloid pergolide. A majority of these organisms formed pergolide sulfoxide, and a Helminthosporium species was investigated in greater detail since it yielded significant amounts of pergolide sulfoxide. A preparative-scale transformation afforded material which was identified as the sulfoxide based on melting point, spectral, and chromatographic comparison with authentic material as well as its conversion to pergolide by reduction with triphenylphosphine. An analytical high-performance liquid chromatographic determination of the enzymatic versus spontaneous air-oxidation of pergolide in growing cultures and controls showed negligible air-oxidation and an ~40% enzymatic conversion of pergolide to the sulfoxide. Several organisms, including Aspergillus alliaceus, formed a second metabolite, pergolide sulfone, which was identified on the basis of co-chromatographic data.
6-N-Propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
-
, (2008/06/13)
6-n-Propyl (ethyl or allyl)-8β-methoxy-(methylsulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonism.
