72825-24-2

Upstream product

• 288-32-4 1H-imidazole 
• 635-84-7 4-(chloroacetyl)biphenyl 
• 135-73-9 2-Bromo-4'-phenylacetophenone 

Downstream Products

• 1206880-85-4 N-[1-(biphen-4-yl)-2-(1H-imidazol-1-yl)ethylidene]-N'-phenylhydrazine 
• 1206880-94-5 2-(biphenyl-4-yl)-3-(1H-imidazo-1-yl)-1H-indole 
• 1345407-14-8 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(4-chlorophenyl)thiosemicarbazone 
• 1345407-16-0 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(2-fluorophenyl)thiosemicarbazone 
• 1345407-18-2 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(4-fluorophenyl)thiosemicarbazone 
• 1345407-17-1 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(3-fluorophenyl)thiosemicarbazone 
• 1345407-15-9 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(2,4-dichlorophenyl)thiosemicarbazone 
• 1345407-12-6 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-phenylthiosemicarbazone 
• 1345407-20-6 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(4-methylphenyl)thiosemicarbazone 
• 1345407-19-3 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(2-methylphenyl)thiosemicarbazone 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 72825-25-3 2-biphenyl-4-yl-1-(4-chloro-phenyl)-3-imidazol-1-yl-propan-2-ol 

Relevant academic research and scientific papers

An efficient and convenient method for synthesis of 1-substituted imidazoles

A convenient method for the synthesis 1-substituted imidazoles was developed by the reaction of α-bromoketone with lithium imidazolide. The reaction gave the desired products in improved yields without the formation of 1,3-disubstituted imidazolium salts. Treatment of bromoacetaldehyde ethylene acetal, 2-(bromomethyl)tetrahydro-2H-pyran, and N-(bromomethyl)phthalimide with lithium imidazolide also gave the corresponding 1-substituted imidazole in good to excellent yields. Direct reaction of α-bromoketone with imidazole as control experiment afforded undesired 1,3-disubstituted imidazolium salts with the desired mono-substituted products.

N-substituted-imidazoles as inhibitors of nitric oxide synthase: A preliminary screening

Identification of potent and selective inhibitors of inducible or neuronat nitric oxide synthase (NOS) is of great interest because of their therapeutic potential for treatment of diseases mediated by overproduction of nitric oxide. Imidazole derivatives

Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles

A novel series of N-(benzoylalkyl)imidazoles and N-(ω-phenyl-ω-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[β-[4-(β-phenylethyl)phenyl]-β-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.