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  • 2-Chloromethyl-3,4-dimethoxypyridinium chloride CAS 72830-09-2 IN Stock 2-(Chloromethyl)-3,4-dimethoxypyridinium hydrochloride 72830-09-2

    Cas No: 72830-09-2

  • USD $ 3.5-5.0 / Kiloliter

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72830-09-2 Usage

Chemical Properties

Light Brown Solid

Uses

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride may be used as a precursor for the preparation [(2-pyridyl)-2-ethyl]-[3,4-dimethoxy-(2-pyridylmethyl)]-N-methylamine.

General Description

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (CDP) can be synthesized using maltol as a starting material. CDP and DMS (dimethyl sulfate) are used in the preparation of pantoprazole sodium (PPS), an antiulcerative drug. The quantification of CDP and DMS in PPS can be done simultaneously by gas chromatography–mass spectrometry (GC-MS) method.

Check Digit Verification of cas no

The CAS Registry Mumber 72830-09-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,8,3 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 72830-09:
(7*7)+(6*2)+(5*8)+(4*3)+(3*0)+(2*0)+(1*9)=122
122 % 10 = 2
So 72830-09-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H10ClNO2.ClH/c1-11-7-3-4-10-6(5-9)8(7)12-2;/h3-4H,5H2,1-2H3;1H

72830-09-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H60235)  2-Chloromethyl-3,4-dimethoxypyridine hydrochloride, 97%   

  • 72830-09-2

  • 1g

  • 247.0CNY

  • Detail
  • Alfa Aesar

  • (H60235)  2-Chloromethyl-3,4-dimethoxypyridine hydrochloride, 97%   

  • 72830-09-2

  • 5g

  • 1000.0CNY

  • Detail
  • Aldrich

  • (530301)  2-(Chloromethyl)-3,4-dimethoxypyridinehydrochloride  97%

  • 72830-09-2

  • 530301-25G

  • 2,304.90CNY

  • Detail

72830-09-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Chloromethyl)-3,4-dimethoxypyridine Hydrochloride

1.2 Other means of identification

Product number -
Other names 2-Chloromethyl-3,4-dimethoxypyridinium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72830-09-2 SDS

72830-09-2Synthetic route

2-hydroxymethyl-3,4-dimethoxypyridine
72830-08-1

2-hydroxymethyl-3,4-dimethoxypyridine

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 2h;100%
With bis(trichloromethyl) carbonate; Triphenylphosphine oxide In toluene at 20 - 60℃; for 4h;98%
With thionyl chloride In dichloromethane at 0 - 5℃; for 2h;93%
Maltol
118-71-8

Maltol

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 68 percent / K2CO3 / acetone / 19 h / Heating
2: 77 percent / conc. ammonia / 3 h / 110 °C
3: 85 percent / POCl3 / 10 h / Heating
4: NaOMe / 10 h / Heating
5: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
6: 4 h / 100 °C
7: 2 M NaOH / 1 h / 100 °C
8: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
Multi-step reaction with 5 steps
1.1: ammonium hydroxide / 2 h / 40 °C
1.2: 10 h / 40 °C / Reflux
2.1: potassium hydroxide / water / 20 h / 10 - 20 °C
3.1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C
4.1: acetic anhydride / 4 h / Reflux
5.1: thionyl chloride / dichloromethane / 2 h / 0 - 15 °C
View Scheme
3-methoxy-2-methyl-4-pyrone
4780-14-7

3-methoxy-2-methyl-4-pyrone

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 77 percent / conc. ammonia / 3 h / 110 °C
2: 85 percent / POCl3 / 10 h / Heating
3: NaOMe / 10 h / Heating
4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
5: 4 h / 100 °C
6: 2 M NaOH / 1 h / 100 °C
7: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
2-methyl-3-methoxy-4(1H)-pyridinone
76015-11-7

2-methyl-3-methoxy-4(1H)-pyridinone

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 85 percent / POCl3 / 10 h / Heating
2: NaOMe / 10 h / Heating
3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
4: 4 h / 100 °C
5: 2 M NaOH / 1 h / 100 °C
6: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
Multi-step reaction with 6 steps
1: 96 percent / POCl3 / 18 h / 90 °C
2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C
3: 91 percent / NaOMe / 18 h
4: 2 h / 90 °C
5: 2 N aq. NaOH / 2 h / 80 °C
6: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 18 h / 90 °C / Inert atmosphere
2.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C
3.1: methanol / 16 h / 40 °C
4.1: acetic anhydride / 2 h / 90 °C
4.2: 2 h / 80 °C
5.1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C
View Scheme
4-Chloro-3-methoxy-2-methyl-pyridine
107512-34-5

4-Chloro-3-methoxy-2-methyl-pyridine

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaOMe / 10 h / Heating
2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature
3: 4 h / 100 °C
4: 2 M NaOH / 1 h / 100 °C
5: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
Multi-step reaction with 5 steps
1: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C
2: 91 percent / NaOMe / 18 h
3: 2 h / 90 °C
4: 2 N aq. NaOH / 2 h / 80 °C
5: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C
2.1: methanol / 16 h / 40 °C
3.1: acetic anhydride / 2 h / 90 °C
3.2: 2 h / 80 °C
4.1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C
View Scheme
3,4-dimethoxy-2-methylpyridine N-oxide
72830-07-0

3,4-dimethoxy-2-methylpyridine N-oxide

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 4 h / 100 °C
2: 2 M NaOH / 1 h / 100 °C
3: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
Multi-step reaction with 3 steps
1: 2 h / 90 °C
2: 2 N aq. NaOH / 2 h / 80 °C
3: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: acetic anhydride / 2 h / 90 °C
1.2: 2 h / 80 °C
2.1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetic acid / methanol; toluene
2: sodium hydroxide / methanol
3: thionyl chloride
View Scheme
5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

pantoprazole sulfide
102625-64-9

pantoprazole sulfide

Conditions
ConditionsYield
With sodium hydroxide In water at 25 - 30℃; for 4 - 5h;97.5%
With sodium hydroxide In methanol; water at 10 - 40℃; for 2.5h;95.3%
With sodium hydroxide In methanol; water at 40 - 55℃; for 3.5h; Temperature; Solvent;93%
tert-butyl 5-(2-mercapto-1H-benzo[d]imidazol-5-yloxy)pentylcarbamate
1261238-09-8

tert-butyl 5-(2-mercapto-1H-benzo[d]imidazol-5-yloxy)pentylcarbamate

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

tert-butyl 5-(2-((3,4-dimethoxypyridin-2-yl)methylthio)-1H-benzo[d]imidazol-5-yloxy)pentylcarbamate
1261238-10-1

tert-butyl 5-(2-((3,4-dimethoxypyridin-2-yl)methylthio)-1H-benzo[d]imidazol-5-yloxy)pentylcarbamate

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 12h; Inert atmosphere;97%
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

3,4-dimethoxy-2-{[(4-nitrophenyl)thio]methyl}pyridine

3,4-dimethoxy-2-{[(4-nitrophenyl)thio]methyl}pyridine

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 20℃; for 8h;93.5%
6-nitro-5-(piperidin-1-yl)-1H-benzimidazole-2-thiol
1319671-85-6

6-nitro-5-(piperidin-1-yl)-1H-benzimidazole-2-thiol

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2-[(3,4-dimethoxypyridin-2-yl)methylthio]-6-nitro-5-(piperidin-1-yl)-1H-benzimidazole
1319671-86-7

2-[(3,4-dimethoxypyridin-2-yl)methylthio]-6-nitro-5-(piperidin-1-yl)-1H-benzimidazole

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In ethanol; acetone at 45℃; for 4h;91%
2,2'-dithiol-5,5'-bis-1H,1'H-benzimidazole
871882-17-6

2,2'-dithiol-5,5'-bis-1H,1'H-benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2,2'-di-[[(3,4-dimethoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole
1075188-15-6

2,2'-di-[[(3,4-dimethoxy)pyridin-2-yl]methylenethio]-5,5'-bis-1H,1'H-benzimidazole

Conditions
ConditionsYield
Stage #1: 2,2'-dithiol-5,5'-bis-1H,1'H-benzimidazole With sodium hydroxide In ethanol; water for 0.5h;
Stage #2: 2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride In ethanol; water for 8h; Reflux;
89%
2,2,2-trifluoroacetamide
354-38-1

2,2,2-trifluoroacetamide

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

N-((3,4-dimethoxypyridin-2-yl)methyl)-2,2,2-trifluoroacetamide

N-((3,4-dimethoxypyridin-2-yl)methyl)-2,2,2-trifluoroacetamide

Conditions
ConditionsYield
Stage #1: 2,2,2-trifluoroacetamide With caesium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: 2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride In tetrahydrofuran at 65℃; for 16h; Inert atmosphere;
57%
betahistine
5638-76-6

betahistine

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

[(2-pyridyl)-2-ethyl]-[(3,4-dimethoxy-2-pyridyl)methyl]-N-methylamine

[(2-pyridyl)-2-ethyl]-[(3,4-dimethoxy-2-pyridyl)methyl]-N-methylamine

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran for 72h; Reflux;56%
11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine
5747-48-8

11-(1-piperazinyl)dibenzo[b,f][1,4]thiazepine

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

C25H26N4O2S

C25H26N4O2S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 0.5h; Sonication;55%
2-(4-(2-(2-aminoethoxy)ethoxy)phenyl)-4H-chromen-4-one

2-(4-(2-(2-aminoethoxy)ethoxy)phenyl)-4H-chromen-4-one

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2-(4-(2-(2-(bis((3,4-dimethoxypyridin-2-yl)methyl)amino)ethoxy)ethoxy)phenyl)-4H-chromen-4-one

2-(4-(2-(2-(bis((3,4-dimethoxypyridin-2-yl)methyl)amino)ethoxy)ethoxy)phenyl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;52%
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

Cyclopropylamine
765-30-0

Cyclopropylamine

N-[(3,4-dimethoxypyridin-2-yl)methyl]cyclopropylamine

N-[(3,4-dimethoxypyridin-2-yl)methyl]cyclopropylamine

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water at 58℃; for 1.5h;42%
5-Difluoromethoxy-6-fluoro-1H-benzoimidazole-2-thiol
97963-64-9

5-Difluoromethoxy-6-fluoro-1H-benzoimidazole-2-thiol

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5-Difluoromethoxy-2-(3,4-dimethoxy-pyridin-2-ylmethylsulfanyl)-6-fluoro-1H-benzoimidazole
138786-84-2

5-Difluoromethoxy-2-(3,4-dimethoxy-pyridin-2-ylmethylsulfanyl)-6-fluoro-1H-benzoimidazole

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50℃; for 2h;
5-difluoromethoxy-2-mercapto-6-methoxy-1H-benzimidazole
97963-65-0

5-difluoromethoxy-2-mercapto-6-methoxy-1H-benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5-difluoromethoxy-6-methoxy-2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-1H-benzimidazole
102625-65-0

5-difluoromethoxy-6-methoxy-2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50℃; for 2h;
2-mercapto-5-(2,2,2-trifluoroethoxy)-1H-benzimidazole
102625-84-3

2-mercapto-5-(2,2,2-trifluoroethoxy)-1H-benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-5-(2,2,2-trifluoroethoxy)-1H-benzimidazole
138786-82-0

2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-5-(2,2,2-trifluoroethoxy)-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50℃; for 2h;
2,2-difluoro-6-mercapto-5H-[1,3]dioxolo-[4,5-f]benzimidazole
97967-01-6

2,2-difluoro-6-mercapto-5H-[1,3]dioxolo-[4,5-f]benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2,2-difluoro-6-[(3,4-dimethoxy-2-pyridyl)methylthio]-5H-[1,3]-dioxolo-[4,5-f]benzimidazole
102625-75-2

2,2-difluoro-6-[(3,4-dimethoxy-2-pyridyl)methylthio]-5H-[1,3]-dioxolo-[4,5-f]benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 60℃; for 4h;
With sodium hydroxide In ethanol; water
2-mercapto-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole
97963-60-5

2-mercapto-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole
102625-63-8

2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50℃; for 2h;
With sodium hydroxide In ethanol; water
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5,6-difluoro-1H-benzo[d]imidazole-2-thiol
123470-47-3

5,6-difluoro-1H-benzo[d]imidazole-2-thiol

2-(3,4-Dimethoxy-pyridin-2-ylmethylsulfanyl)-5,6-difluoro-1H-benzoimidazole

2-(3,4-Dimethoxy-pyridin-2-ylmethylsulfanyl)-5,6-difluoro-1H-benzoimidazole

Conditions
ConditionsYield
With sodium hydroxide In methanol
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium bicarbonate / CHCl3
1.2: 84 percent / m-chloroperbenzoic acid / 2.42 h / 5 °C
2.1: 98.44 percent / potassium carbonate / dimethylformamide / 20 °C
3.1: m-chloroperbenzoic acid / CH2Cl2 / 2.67 h / 0 °C
View Scheme
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfinyl]-1H-benzoimidazole

5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl-1-oxide)methylsulfinyl]-1H-benzoimidazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium bicarbonate / CHCl3
1.2: 84 percent / m-chloroperbenzoic acid / 2.42 h / 5 °C
2.1: 98.44 percent / potassium carbonate / dimethylformamide / 20 °C
3.1: m-chloroperbenzoic acid / CH2Cl2 / 2.67 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydroxide / dichloromethane / 2 h / 20 - 30 °C
2: acetic acid; dihydrogen peroxide; copper(II) hydroxide phosphate / 5 h / 45 °C
View Scheme
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
72830-09-2

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole
953787-51-4

5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium bicarbonate / CHCl3
1.2: 84 percent / m-chloroperbenzoic acid / 2.42 h / 5 °C
2.1: 98.44 percent / potassium carbonate / dimethylformamide / 20 °C
View Scheme

72830-09-2Relevant articles and documents

Preparation of Pantoprazole sodium method and Pantoprazole sodium (by machine translation)

-

Paragraph 0168-0170, (2019/02/27)

The invention relates to the preparation of Pantoprazole sodium method and pantoprazole sodium. In particular, the invention relates to a method of preparing pantoprazole sodium, comprising the following steps: 1) to 2 - hydroxymethyl - 3, 4 - dimethoxy pyridine (II) as the starting material, in under the action of chloride, the compound of formula III; 2) will be of the formula III compound in the presence of an inorganic base with 5 - difluoro - 2 - mercapto - 1 H - benzimidazole condensation, the compound of formula IV; 3) will be of the formula IV compound is oxidized by an oxidant generating 5 - difluoro - 2 - [(3, 4 - dimethoxy - 2 - pyridyl) methyl] sulfinyl - 1 H - benzimidazole is pantoprazole; 4) the obtained 5 - difluoro - 2 - [(3, 4 - dimethoxy - 2 - pyridyl) methyl] sulfinyl - 1 H - benzimidazole with sodium hydroxide reaction to produce salt that pantoprazole sodium (I); and optionally a 5) the resulting pantoprazole sodium is refined. The method of the invention said product has high purity, and the related impurities such as oxidation impurity, reducing the impurity, decomposition low impurity content. (by machine translation)

Method for preparing high-purity razole intermediate and medicine by using green technology instead of phosgene, thionyl chloride and other toxic and harmful substances

-

Paragraph 0079; 0080, (2017/09/01)

The invention discloses a method for preparing a high-purity razole intermediate and a medicine by using a green technology instead of phosgene, thionyl chloride and other toxic and harmful substances. The preparation method comprises the following steps: dissolving Ph3PO in an organic solvent, placing the obtained solution in a reaction bottle, dropwise adding BTC to form a high-efficiency chloration reagent, carrying out a heat insulation reaction for a period of time after the dropwise addition is finished, dissolving a razole hydroxide in the organic solvent, dropwise adding the obtained solution to the above system, carrying out a heat insulation reaction for a period of time, carrying out suction filtration, and drying the obtained dried reaction product to obtain razole chloride. In the process, the Ph3PO is equivalently regenerated, a mother liquor part is concentrated to precipitate the Ph3PO at a low temperature, and the Ph3PO can be repeatedly used after being washed with a solvent with small polarity. The method has the advantages of few side reactions, high product quality, few "three wastes" pollutions, high atomic economy, and good promotion and application prospect. The invention also provides a relevant razole medicine prepared from the razole chloride obtained through the green technology. The medicine has obviously higher purity than medicines obtained through traditional methods.

Synthesis of a DOTA (Gd3+)-conjugate of proton-pump inhibitor pantoprazole for gastric wall imaging studies

Maharvi, Ghulam M.,Bharucha, Adil E.,Fauq, Abdul H.

, p. 2808 - 2811 (2013/06/27)

Magnetic resonance imaging (MRI) is used to evaluate gastrointestinal (GI) structure and functions in humans. Despite filling the viscus lumen with a contrast agent, visualization of the viscus wall is limited. To overcome this limitation, we de novo synthesized a conjugate that covalently combines a Gd-based MRI contrast agent, encaged with a chelating agent (DOTA), with pantoprazole, which is a widely used proton pump inhibitor that binds to proton pumps in the stomach and colon. The DOTA linkage was installed at a mechanism-based strategic location in the pantoprazole molecule to minimize a possible negative effect of the structural modification on the drug. It is anticipated that by defining the wall of the stomach and colon, this compound will facilitate functional MRI of the GI tract in humans.

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