72833-80-8Relevant academic research and scientific papers
Enaminones in heterocyclic synthesis: Synthesis and chemical reactivity of 3-anilino-1-substituted-2-propene-1- one
Al-Saleh, Balkis,El-Apasery, Morsy Ahmed,Abdel-Aziz, Rasha Safwat,Elnagdi, Mohamed Hilmy
, p. 563 - 566 (2005)
The 3-anilinoenones 3a,b were prepared from the corresponding 3-dimethyl-aminopropenones. The reactivity of 3a,b towards a variety of carbon and nitrogen nucleophiles as well as naphthoquinones is reported.
Biological evaluation of isoegomaketone isolated from perilla frutescens and its synthetic derivatives as anti-inflammatory agents
Park, Yong Dae,Jin, Chang Hyun,Choi, Dae Seong,Byun, Myung-Woo,Jeong, Il Yun
experimental part, p. 1277 - 1282 (2012/05/20)
The anti-inflammatory activities of a prepared isoegomaketone 3a and its derivatives 3b-3f were evaluated in RAW 264.7 cells. Among these, the compound 3d was displayed the most potent inhibitory activities against production of nitric oxide, monocyte chemoattractant protein- 1 and interleukin-6. Based on these results, the abilities of compounds 3a-3f to modulate NF-κB and AP-1-mediated gene transcription using a luciferase reporter assay were investigated. The transcriptional activities of NF-κB and AP-1 decreased when pretreated with 3a- 3f. Interestingly, at 10 μM, compound 3d markedly suppressed the lipopolysaccharide-induced NF-κB and activator protein-1 DNA binding activities. Some preliminary structure-activity relationships were proposed that may provide a direction for further study.
6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists
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Page/Page column 16, (2008/12/08)
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: Formula (I) where: R6 is selected from the group consisting of (a, b, c, d, e) and other substituents are as defined in the specification.
Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
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, (2008/06/13)
This disclosure describes substituted pyrazolo[1,5-a]pyrimidines which possess anxiolytic activity.
