72848-93-2Relevant academic research and scientific papers
Radioisotopic and synthetic studies related to caroxazone metabolism in man
Bernardi,Coda,Nicolella,Vicario,Gioia,Minghetti,Vigevani,Arcamone
, p. 1412 - 1416 (2007/10/10)
Labelled 2-oxo-2H-1,3-benzoxazine-3(4H)-acetamide (caroxazone), has been synthesized by condensing N-(2-hydroxylbenzyl)glycinamide with 14C phosgene. Metabolic studies were performed administering the labelled drug to man and recovering metabolites from the urines. Beside the unchanged drug, five metabolites were identified and confirmed by synthesis, namely (3,4-dihdydro-3-carboxamidomethyl-2-oxo-2H-1,3-benzoxazin-4-yl)urea, N-carboxamidomethyl o-hydroxymethylphenyl carbamate, 4-methoxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide, 2-oxo-2H-1,3-benzoxazine-3(4H)acetic acid, and 4-hydroxy-2-oxo-2H-1,3-benzoxazine-3(4H)acetamide.
