72850-74-9Relevant academic research and scientific papers
BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS
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Page/Page column 200; 223, (2021/04/17)
Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, and Q are defined herein.
Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates
Lee, Len F.,Schleppnik, Francis M.,Howe, Robert K.
, p. 1621 - 1630 (2007/10/02)
A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.
2-Amino-4-substituted-thiazolecarboxylic acids and their derivatives
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, (2008/06/13)
2-Amino-4-substituted-5-thiazolecarboxylic acids and derivatives thereof, are intermediates for the preparation of 2-substituted-4-substituted-5-thiazolecarboxylic acid derivatives which are herbicidal safeners.
