728896-87-5

Upstream product

• 728896-86-4 N-(tert-butyloxycarbonyl)-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester 
• 13734-41-3 t-Boc-L-valine 
• 625386-12-1 5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester 

Downstream Products

• 849599-82-2 N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester 
• 849599-83-3 5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester 
• 940964-35-2 N^ε-tert-butyloxycarbonyl-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

β-sheet ligands in action: KLVFF recognition by aminopyrazole hybrid receptors in water

Little is known about the precise mechanism of action of β-sheet ligands, hampered by the notorious solubility problems involved with protein misfolding and amyloid formation. Recently the nucleation site for the pathogenic aggregation of the Alzheimer's