729-42-0Relevant academic research and scientific papers
Diastereoselective synthesis of cyclopropanes bearing trifluoromethyl-substituted all-carbon quaternary centers from 2-trifluoromethyl-1,3-enynes beyond fluorine elimination
Chen, Shujie,Zhang, Jinhui,Yang, Mingfeng,Liu, Fenggang,Xie, Zhipeng,Liu, Yunlin,Lin, Wenxia,Wang, Daru,Li, Xiangrui,Wang, Jiahai
, p. 3879 - 3882 (2019)
Herein, a one-pot, two-step procedure for the diastereoselective synthesis of cyclopropanes bearing trifluoromethyl-substituted all-carbon quaternary centers has been described. Trifluoromethyl-activated 1,3-enynes undergo cyclopropanation reactions with sulfur ylides under mild reaction conditions without fluoride elimination, which affords the cis-isomer mainly. Interestingly, a sequential TBAF-mediated deprotection of the triisopropylsilyl group results in a diastereoenriched epimerization which gives rise to the trans-cyclopropanes as the sole isomers.
Oxo-Thiolation of Cationically Polymerizable Alkenes Using Flow Microreactors
Ashikari, Yosuke,Saito, Kodai,Nokami, Toshiki,Yoshida, Jun-ichi,Nagaki, Aiichiro
supporting information, p. 15239 - 15243 (2019/11/13)
The present study describes the cationic oxo-thiolation of polymerizable alkenes by using highly reactive cationic species generated by anodic oxidation. These highly reactive cations were able to activate alkenes before their polymerization. Fast mixing in flow microreactors effectively controlled chemoselectivity, enabling higher reaction temperatures.
