72917-83-0

Basic information

• Product Name: (S)-2-[(S)-2-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester
• CAS NO: 72917-83-0
• Molecular Weight: 577.762
• Mol File: 72917-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[(S)-2-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(S)-2-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester(72917-83-0)
• EPA Substance Registry System: (S)-2-[(S)-2-((S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester(72917-83-0)

Safety Data

• Hazardous Substances Data: 72917-83-0(Hazardous Substances Data)

Upstream product

• 2748-02-9 L-leucine tert-butyl ester hydrochloride 
• 64817-69-2 symmetric anhydride of Boc-Ser(Bzl)-OH 

Relevant articles and documents

Polymer-Bound Oxime Esters as Supports for Solid-Phase Peptide Synthesis. Preparation of Protected Peptide Fragments.

A series of polystyrene-bound substituted benzophenone oximes (II) have been synthesized and tested as potential supports for the solid-phase preparation of protected peptide fragments.The polymer-bound p-nitrobenzophenone oxime (IID) has been found to be a suitable support for stepwise peptide synthesis.Protected peptides can be assembled on IID by coupling and deprotection steps similar to those employed in the usual Merrifield solid-phase procedures.Cleavage of peptides from IID can be accomplished with hydrazine and amino acid esters under mild conditionswhich do not affect benzyl ester side-chain protecting groups.The utility of IID has been illustrated in the synthesis of protected peptide hydrazides and esters, several of which have aspartic and glutamic acid side chains protected by benzyl groups.