7292-42-4

Basic information

• Product Name: adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate]
• Synonyms: adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate];(α,β-Methylene)adenosine triphosphate;Adenosine 5'-[[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate];Adenosine 5'-[[hydroxy(phosphonooxy)phosphinyl]methyl] phosphonate;Adenosine-5'-methylenediphosphono-P2-phosphate;5'-(Hydrogen((hydroxy(phosphonooxy)phosphinyl)methyl)phosphonate)adenosine;Einecs 230-723-9;α,β-Methyleneadenosine 5'-triphosphate trisodium salt
• CAS NO: 7292-42-4
• Molecular Formula: C₁₁H₁₈N₅O₁₂P₃
• Molecular Weight: 505.208203
• EINECS: 230-723-9
• Mol File: 7292-42-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 968.2±75.0 °C(Predicted)
• Appearance: /
• Density: 2.50±0.1 g/cm3(Predicted)
• Storage Temp.: Store at -20°C
• PKA: 0.56±0.10(Predicted)
• CAS DataBase Reference: adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate](CAS DataBase Reference)
• NIST Chemistry Reference: adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate](7292-42-4)
• EPA Substance Registry System: adenosine 5'-[hydrogen [[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate](7292-42-4)

Safety Data

• Hazardous Substances Data: 7292-42-4(Hazardous Substances Data)

Usage

Uses

α,β-Methyleneadenosine 5''-Triphosphate is a P2-purinoceptor agonist.

Biological Activity

P2-purinoceptor agonist. Also shown to inhibit adenylate cyclase (K i = 0.5 μ M).

Upstream product

• 157728-69-3 N,N-diisopropyl-bis<2-(methylsulfonyl)ethyl> phosphoramidite 

Relevant articles and documents

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates

A new class of phosphanylmethylphosphonate reagents has been developed to enable the controlled synthesis of methylene bisphosphonate mono- and diesters. Condensation of such reagents with an alcohol of choice through azole-mediated phosphoramidite chemistry followed by in situ oxidation provides orthogonally protected methylene bisphosphonate tetraesters. Global deprotection of the tetraester leads to terminal methylene bisphosphonates. Alternatively, selective deprotection at the terminal phosphonate followed by a condensation between the acquired methylene bisphosphonate triester and a second alcohol leads to methylene bisphosphonates diesters.