72928-39-3Relevant academic research and scientific papers
Polyalkynyl-containing alpha, beta-diamino acid ester derivative compound as well as preparation and application of thereof
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, (2021/04/28)
The invention discloses a polyalkynyl-containing alpha, beta-diamino acid ester derivative compound or a pharmaceutically acceptable salt, and an application of the compound or a pharmaceutical composition containing the compound in treating various malignant tumor related diseases such as osteosarcoma, pancreatic cancer, head and neck tumors and the like. The invention further relates to a preparation method of the polyalkynyl-containing alpha, beta-diamino acid ester derivative compound or the pharmaceutically acceptable salt.
Photoinduced Diverse Reactivity of Diazo Compounds with Nitrosoarenes
Roy, Sourav,Kumar, Gourav,Chatterjee, Indranil
supporting information, p. 6709 - 6713 (2021/09/08)
A diverse reactivity of diazo compounds with nitrosoarene in an oxygen-transfer process and a formal [2 + 2] cycloaddition is reported. Nitosoarene has been exploited as a mild oxygen source to oxidize an in situ generated carbene intermediate under visible-light irradiation. UV-light-mediated in situ generated ketenes react with nitosoarenes to deliver oxazetidine derivatives. These operationally simple processes exemplify a transition-metal-free and catalyst-free protocol to give structurally diverse α-ketoesters or oxazetidines.
Enantioselective Addition of Alkynyl Esters and Ethers to Aldehydes Catalyzed by a Cyclopropyl Amino Alcohol Based Zinc Catalyst
Bian, Qinghua,Li, Fengqi,Li, Shuoning,Ma, Sijie,Walsh, Patrick J.,Wang, Lifeng,Wang, Min,Zhong, Jiangchun,Zhou, Yun
supporting information, p. 60 - 64 (2019/12/30)
A novel and highly enantioselective synthesis of hydroxyalkynyl esters and ethers through the asymmetric addition of alkynyl esters or ethers to aldehydes promoted by a cyclopropyl amino alcohol based zinc catalyst has been developed. The method afforded a library of new enantioenriched hydroxyalkynol esters and ethers (up to 93percent yield; 95percent ee), and it was compatible with a broad range of functional groups. Moreover, it could be used in the synthesis of carbon-chain-elongated enantioenriched hydroxyalkynol esters and (2 R,5 R)-musclide-A1, a cardiotonic potentiating principle from musk.
Rhodium-catalysed synthesis of fused pyrimidine derivatives employing N-sulfonyl-1,2,3-triazoles as a 1-aza-[4C] synthon
Xu, Ze-Feng,An, Yuehui,Chen, Yidian,Duan, Shengguo
supporting information, p. 1849 - 1853 (2019/06/20)
A new synthetic application of N-sulfonyl-1,2,3-triazoles acting as a 1-aza-[4C] synthon via the 1,2-shift reaction of an α-imine rhodium carbene was developed for the synthesis of fused pyrimidine derivatives. The high reactivity of the strained three-me
Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)3·9H2O
Thurow, Samuel,Fernandes, Alessandra A. G.,Quevedo-Acosta, Yovanny,De Oliveira, Matheus F.,De Oliveira, Marcelo G.,Jurberg, Igor D.
supporting information, p. 6909 - 6913 (2019/09/12)
A thermal protocol is reported for the formal insertion of nitric acid into aryldiazoacetates using Fe(NO3)3·9H2O. This strategy is mild and high yielding and allows the preparation of a large variety of members of an unprecedented family of organic nitrates. The nitrate group can be also readily transformed into other functional groups and heterocyclic moieties and can possibly allow new biological explorations of untapped potential associated with their NO-releasing ability.
Gold(I)-Catalyzed and H2O-Mediated Carbene Cascade Reaction of Propargyl Diazoacetates: Furan Synthesis and Mechanistic Insights
Bao, Ming,Qian, Yu,Su, Han,Wu, Bing,Qiu, Lihua,Hu, Wenhao,Xu, Xinfang
supporting information, p. 5332 - 5335 (2018/09/13)
A novel gold-catalyzed water-mediated carbene cascade reaction of propargyl diazoacetates has been developed. Mechanistic investigation indicates that this reaction is initiated by gold-catalyzed gold-carbene formation followed by an unprecedented 6-endo-
The carbon material functionalized with NH2+ and SO3H groups catalyzed esterification with high activity and selectivity
Zhan, Shaoqi,Tao, Xiaochun,Cai, Liangzhen,Liu, Xiaohui,Liu, Taoping
supporting information, p. 4649 - 4653 (2015/02/19)
A novel carbon-based solid acid was conveniently prepared by heating a mixture of d-glucose, p-toluenesulfonic acid and diphenylammonium tosylate. Its structure was measured by XRD, FT-IR, XPS, 13C MAS NMR and EA to illustrate that the carbon material has been functionalized with NH2+ and SO3H groups and has a strong "hydrophobic effect". It can be used to catalyze the esterification reaction of carboxylic acids with equimolar amounts of sterically demanding and acid-sensitive alcohols with high reactivity (yield up to 90%) and selectivity (up to 95%) in heptane at 80 °C. It could be easily recovered and reused more than ten times without loss of activity.
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies
Liang, Zhongjie,Zhang, Liying,Li, Lianchun,Liu, Jun,Li, Hongling,Zhang, Luyong,Chen, Limin,Cheng, Keguang,Zheng, Mingyue,Wen, Xiaoan,Zhang, Pu,Hao, Jia,Gong, Yanchun,Zhang, Xia,Zhu, Xiaoyun,Chen, Jun,Liu, Hong,Jiang, Hualiang,Luo, Cheng,Sun, Hongbin
supporting information; experimental part, p. 2011 - 2021 (2011/06/22)
Naturally occurring pentacyclic triterpenes (PT), a novel class of inhibitors against glycogen phosphorylase (GP), hold promise for the treatment of type-2 diabetes and other diseases with disorders in glycogen metabolism. To identify novel and more potent GP inhibitors, the receptor-based comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) approaches were performed to investigate the quantitative structure-activity relationships (QSAR) among 106 PT analogues. The validated models demonstrated that the elongated or bulky substitutions in C17 position and/or C2, C3 positions are favorable. Then based on the structural information extracted from these models, 56 derivatives were synthesized and biochemically tested in this study. The IC50 value of the most potent compound P50 was found to be 1.1 μM.
Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors
Chaudhary, Preeti M.,Chavan, Sayalee R.,Shirazi, Fazal,Razdan, Meenakshi,Nimkar, Prachi,Maybhate, Shailaja P.,Likhite, Anjali P.,Gonnade, Rajesh,Hazara, Braja G.,Deshpande, Mukund V.,Deshpande, Sunita R.
body text, p. 2433 - 2440 (2009/09/05)
Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked uridine derivatives 19a-19g and 21a-21g was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of 5′-azido-5′-deoxy-2′,3′-O-(1-methylethylidene)uridine (17) with p
