72936-38-0

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(NitroMethyl)cyclopentanol is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for versatile chemical reactions, facilitating the creation of a wide range of medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 1-(NitroMethyl)cyclopentanol serves as a crucial component in the production of various agrochemicals. Its incorporation aids in the development of effective pesticides, herbicides, and other agricultural chemicals that are essential for maintaining crop health and productivity.
Used in Material Development:
1-(NitroMethyl)cyclopentanol has been studied for its potential use in the development of new materials. Its unique properties and reactivity make it a promising candidate for the creation of innovative materials with specific applications in various industries.
Used as a Reagent in Organic Synthesis:
As a reagent in organic synthesis, 1-(NitroMethyl)cyclopentanol plays a vital role in facilitating specific chemical reactions. Its presence can enhance the efficiency and selectivity of certain synthetic processes, making it an indispensable tool for chemists in various research and industrial settings.
Safety Considerations:
Given its moderate acute toxicity, 1-(NitroMethyl)cyclopentanol is considered hazardous if ingested or inhaled. It is essential to handle 1-(nitroMethyl)cyclopentanol with care and adhere to proper safety protocols to minimize risks associated with its use.

Upstream product

• 75-52-5 nitromethane 
• 120-92-3 cyclopentanone 

Downstream Products

• 1430853-32-9 (4S,5R)-4-phenyl-5-nitro-1-oxaspiro[5.4]decan-2-one 
• 1430853-19-2 C₁₅H₁₈ClNO₄ 
• 45511-81-7 1-(aminomethyl)-1-hydroxycyclopentane 
• 2562-42-7 1-nitromethylcyclopentene 
• 335458-23-6 1-benzylthio-1-nitromethylcyclopentane 

Relevant academic research and scientific papers

Ketones as electrophile in nitroaldol reaction: Synthesis of β,β-disubstituted-1,3-dinitroalkanes and allylic nitro compounds

β,β-Disubstituted-1,3-dinitro compounds were obtained exclusively with an overall yield of 83% through a domino nitroaldol/elimination/1,4-addition process, when excess nitromethane was added to cyclohexanone or butanone using DBU (1,8-diazabicyclo[5.4.0]

Method for taking DAST reagent as removing reagent to synthetize conjugated nitroolefin substituted series derivative

The invention discloses a preparation method of taking a DAST reagent as a removing reagent to synthesize a conjugated nitroolefin substituted series derivative. The preparation method comprises the following steps that a carbonyl compound (compound II) i

Asymmetric organocatalytic Michael-hemiacetalization reaction: Access to chiral spiro cis-δ-lactones by in situ oxidation of spiro δ-lactols

Asymmetric tandem Michael-hemiacetalization reaction between 1-nitromethylcycloalkanol and α,β-unsaturated aldehydes was investigated, which provided an efficient and facile synthesis for spiro cis-δ-lactones by in situ oxidation of spiro δ-lactols in goo

Methylcarbonate and bicarbonate phosphonium salts as catalysts for the nitroaldol (Henry) reaction

Phosphonium ionic liquids exchanged with bicarbonate and methylcarbonate anions (CILs) exhibit catalytic performances comparable to those of sterically hindered (non nucleophilic) organosuperbases such as DBU. At 25-50 °C, under solventless conditions, CI

Sulfone substituted imidazo ring ethers

Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutica

Rapid microwave-assisted Henry reaction in solvent-free processes

The solvent-free Henry reactions of nitromethane with a series of carbonyl compounds were studied under microwave irradiation. By using different bases and Lewis acids, the solvent-free nitroaldol reaction of aldehydes were realized under microwave condition, affording the corresponding adducts with high yields. Particularly, aliphatic ketones, which were hardly carried out this reaction, could be the reaction substrates in the nitroaldol reactions by employment of 1,4-diazabicyclo[2.2.2]octane (DABCO) under a similar conditions, giving the corresponding adducts with moderate to good yields. Georg Thieme Verlag Stuttgart.

SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZOPYRIDINES, AND IMIDAZONAPHTHYRIDINES

Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines, [1,5]tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

ARYL SUBSTITUTED IMIDAZONAPHTHYRIDINES

Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of

An efficient method for the preparation of β-nitroalkanols in room temperature ionic liquids

β-Nitroalkanols were obtained in good to high yields from carbonyl substrates and nitroalkanes in the room temperature ionic liquids using DBU as catalyst under mild reaction conditions and short reaction times.

P(RNCH2CH2)3N: An Efficient Promoter for the Nitroaldol (Henry) Reaction

The use of catalytic amounts of the proazaphosphatranes P(MeNCH2CH2)3N, P(i-PrNCH2CH2)3N and P(HNCH2CH2)(i-PrNCH2CH2) 2N as nonionic bases in the reaction of nitroalkanes with carbonyl compounds is reported. The reaction proceeds at room temperature in the presence of 2.2 equiv of magnesium sulfate to produce the corresponding β-nitroalkanols in generally superior yields. Aldehydes react quantitatively in 5-60 min, whereas ketones require up to 3 h to react with nitromethane and up to 7 h for the reaction of ketones with higher nitroalkanes.