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72955-81-8

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72955-81-8 Usage

Chemical Properties

Brownish-Oil

Check Digit Verification of cas no

The CAS Registry Mumber 72955-81-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,9,5 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72955-81:
(7*7)+(6*2)+(5*9)+(4*5)+(3*5)+(2*8)+(1*1)=158
158 % 10 = 8
So 72955-81-8 is a valid CAS Registry Number.

72955-81-8Relevant articles and documents

Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: Synthesis, biological evaluation, and α1d computational study

Carrieri, Antonio,Piergentili, Alessandro,Bello, Fabio Del,Giannella, Mario,Pigini, Maria,Leonardi, Amedeo,Fanelli, Francesca,Quaglia, Wilma

experimental part, p. 7065 - 7077 (2010/11/02)

A series of novel openphendioxan analogues were synthesized and tested at α1-adrenoreceptor (AR) subtypes by binding and functional assays. The α1d-AR binding profile was also examined by means of 2D, 3D-QSAR together with docking studies. Multiple regression analysis suggested the relevance of adequate number of heteroatoms in the whole molecule and of passive membrane diffusion to enhance α1d-AR affinity. Docking simulations against a computational structural model of the biological target further proved this evidence and furnished support for chemiometric analysis, where polar, electrostatic, hydrophobic and shape effects of the ortho substituents in the phenoxy terminal, most likely governing ligand binding, helped the depiction of pharmacophore hypothesis for the examined ligands data set.

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