72955-97-6

Basic information

• Product Name: 5-Fluoro-2-methoxyphenol
• Synonyms: 4-fluoro-2-hydroxyanisole;5-FLUORO-2-METHOXYPHENOL;5-fluoro-2-metoxyphenol ;5-Fluoro-2-methoxyphenol98%;2-Hydroxy-4-fluoroanisole;2-Hydroxy-4-fluoroanisole, 4-Fluoro-2-hydroxyphenyl methyl ether, 5-Fluoroquaiacol;2-Hydroxy-4-fluoroanisole, 4-Fluoro-2-hydroxyphenyl methyl ether, 5-Fluoroguaiacol;2-Hydroxy-4-fluoroanisole, 5-Fluoroguiacol
• CAS NO: 72955-97-6
• Molecular Formula: C₇H₇FO₂
• Molecular Weight: 142.13
• Product Categories: Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Phenols
• Mol File: 72955-97-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 223°C
• Flash Point: 111°C
• Appearance: /
• Density: 1.224
• Vapor Pressure: 0.0645mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: 2-8°C
• PKA: 8.97±0.10(Predicted)
• CAS DataBase Reference: 5-Fluoro-2-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-methoxyphenol(72955-97-6)
• EPA Substance Registry System: 5-Fluoro-2-methoxyphenol(72955-97-6)

Safety Data

• Hazard Codes: C,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 72955-97-6(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-methoxyphenol is a chemical compound with the molecular formula C7H7FO2. It is a derivative of phenol with a fluorine atom and a methoxy group attached to the benzene ring. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of fragrances and flavors for the food and cosmetic industries. 5-Fluoro-2-methoxyphenol has potential medicinal properties and has been studied for its potential use in the treatment of various diseases and conditions. It is important to handle this chemical with care as it may pose hazards if not used properly.

InChI:InChI=1/C7H7FO2/c1-10-7-3-2-5(8)4-6(7)9/h2-4,9H,1H3

Upstream product

• 452-08-4 2-bromo-4-fluoro-1-methoxybenzene 
• 126209-85-6 Formic acid 5-fluoro-2-methoxy-phenyl ester 
• 179897-94-0 (5-fluoro-2-methoxyphenyl)boronic acid 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 
• 496-69-5 2-bromo-4-fluoro-phenol 

Downstream Products

• 367-32-8 4-fluoropyrocatechol 
• 126209-86-7 2-(5-Fluoro-2-methoxy-phenoxy)-benzoic acid methyl ester 
• 154051-85-1 5-fluoro-2-methoxy-benzyloxybenzene 
• 125960-66-9 2-(5-fluoro-2-methoxy-phenoxy)ethylchloride 
• 120352-00-3 2-(5-fluoro-2-methoxy-phenoxy)ethylamine 
• 245762-29-2 2-(5-fluoro-2-methoxyphenoxy)ethyl azide 
• 140146-47-0 2-(2-fluoro-4-hydroxy-5-methoxyphenyl)acetic acid 
• 141554-67-8 3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine 
• 154051-86-2 3-methoxy-4-benzyloxy-6-fluorobenzyl chloride 
• 154051-90-8 3-methoxy-4-benzyloxy-6-fluorophenylacetonitrile 
• 154051-91-9 3-methoxy-4-benzyloxy-6-fluorophenylethylamine 
• 154051-92-0 3-methoxy-4-benzyloxy-6-fluorophenylacetic acid 
• 126209-87-8 2-(5-Fluoro-2-methoxy-phenoxy)-benzoic acid 
• 72955-98-7 2-(5-fluoro-2-methoxyphenoxy)-ethanol 

Relevant articles and documents

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

New series of morpholine and 1,4-oxazepane derivatives as dopamine D 4 receptor ligands: Synthesis and 3D-QSAR model

Since the identification of the dopamine D43 receptor subtype and speculations about its possible involvement in schizophrenia, much work has been put into development of selective D4 ligands. These selective ligands may be effective antipsychotics without extrapyramidal side effects. This work describes the synthesis of a new series of 2,4-disubstituted morpholines and 2,4-disubstituted 1,4-oxazepanes with selectivity for the dopamine D4 receptor. A 3D-QSAR analysis using the GRID/GOLPE methodology was performed with the purpose to get a better understanding of the relationship between chemical structure and biological activity. Inspection of the coefficient plots allowed us to identify that regions which are important for affinity are situated around the two benzene ring systems, a p-chlorobenzyl group, and the aliphatic amine belonging to the morpholine or 1,4-oxazepane system. In addition, the size of the morpholine or 1,4-oxazepane ring seems to be important for affinity.

THE SYNTHESIS OF 1-AMINOXANTHONES

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