729559-16-4

Upstream product

• 108-94-1 cyclohexanone 
• 146374-27-8 S-tert-butylsulfinimide 

Downstream Products

• 335593-76-5 N-cyclohexylidene-tert-butanesulfonamide 
• 861857-60-5 2-methylpropane-2-sulfinic acid [1-(3-methoxyphenyl)-cyclohexyl]-amide 
• 1133989-31-7 N-(1-methylcyclohexyl)-tert-butanesulfinamide 
• 861857-81-0 1-(4-tert-butyl-phenyl)-cyclohexylamine hydrochloride 
• 861857-59-2 3-[1-(2-methylpropane-2-sulfinylamino)-cyclohexyl]-benzoic acid ethyl ester 
• 861857-79-6 2-methylpropane-2-sulfinic acid {1-[3-(1,1-dimethyl-2-triisopropylsilanyloxyethyl)-phenyl]-cyclohexyl}-amide 
• 5498-74-8 2-oxo-1-azaspiro<4.5>decane 
• 138313-49-2 N-(1-Ethenylcyclohexyl)formamid 
• 111709-87-6 amino-1 vinyl-1 cyclohexane 
• 1431851-25-0 2-methyl-N-(1-vinylcyclohexyl)propane-2-sulfinamide 
• 108-91-8 cyclohexylamine 
• 1263416-49-4 C₁₈H₂₇NO₄S 
• 1263416-48-3 C₁₁H₂₃NO₂S 
• 1256345-29-5 C₃₆H₆₃N₅O₇S 

Relevant academic research and scientific papers

CARBOCYCLIC PROLINAMIDE DERIVATIVES

This invention is directed to novel carbocyclic prolinamide derivatives of Formula (I), and pharmaceutically acceptable salts, solvates, solvates of the salt and prodrugs thereof, useful in the prevention (e.g., delaying the onset of or reducing the risk

Synthesis of polycyclic tertiary carbinamines by samarium diiodide mediated cyclizations of indolyl sulfinyl imines

Samarium diiodide mediated cyclizations of N-acylated indole derivatives bearing sulfinyl imine moieties afforded polycyclic tertiary carbinamines with moderate to excellent diastereoselectivities. Lithium bromide and water turned out to be the best additives to achieve these transformations in good yields. Using enantiopure sulfinyl imines the outcome strongly depends on the reactivity of the indole moiety. Whereas with unactivated indole derivatives desulfinylation and formation of racemic products was observed, indoles bearing electron-withdrawing substituents at C-3 afforded the polycyclic products with intact N-sulfinyl groups and with excellent diastereoselectivity, finally allowing the preparation of enantiopure tertiary carbinamines. The mechanisms of these processes are discussed.

ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF β-AMINO-α- HYDROXY AMIDES

Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure-activity relationship of the aryl region

The structure-activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-gp liability compared to benzyl amine analog 1.

Recycling the tert-butanesulfinyl group in the synthesis of amines using tert-butanesulfinamide

A practical process for recycling the tert-butanesulfinyl group upon deprotection of N-tert-butanesulfinyl amines has been achieved. Treatment of N-tert-butanesulfinyl amines with HCl in cyclopentyl methyl ether results in complete conversion to tert-butanesulfinyl chloride and the corresponding amine hydrochloride salt, which is isolated by filtration in analytically pure form and in quantitative yield. Treatment of the resulting sulfinyl chloride solution with aqueous ammonia then provides analytically pure tert-butanesulfinamide in 97% yield. Alternatively, the tert-butanesulfinyl chloride solution can be treated with ethanol and catalytic quinidine as a sulfinyl transfer catalyst to provide a cyclopentyl methyl ether solution of ethyl tert-butanesulfinate with 88% ee. Addition of NaNH2 in ammonia followed by simple trituration of the product with octane provides tert-butanesulfinamide with 99% ee and in 67% overall isolated yield based upon the starting N-tert-butanesulfinyl amine.

Preparation of cyclic N-tert-butylsulfonyl enamines by Rh(II)-mediated ring expansion of α-diazoesters

The anion derived from ethyl diazoacetate adds to N-tert-butylsulfonyl ketimines to give β-tert-butylsulfonylamino α-diazoesters, which are further transformed into cyclic enamines by treatment with Rh 2(OAc)4, through 1,2-C-C bond m

A general method for the preparation of N-sulfonyl aldimines and ketimines

(Chemical Equation Presented) A simple procedure to obtain N-sulfonyl imines involving the condensation of carbonyl compounds with p-tolyl or tert-butyl sulfinamides followed by oxidation with m-CPBA of the resulting N-sulfinylimines is reported. The meth

SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.