729611-59-0Relevant academic research and scientific papers
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists
Kambe, Tohru,Maruyama, Toru,Nakai, Yoshihiko,Yoshida, Hideyuki,Oida, Hiroji,Maruyama, Takayuki,Abe, Nobutaka,Nishiura, Akio,Nakai, Hisao,Toda, Masaaki
, p. 2235 - 2251 (2012/05/20)
To identify potent EP2/EP4 dual agonists with excellent subtype selectivity, a series of γ-lactam prostaglandin E analogs bearing a 16-phenyl ω-chain were synthesized and evaluated. Structural hybridization of 1 and 2, followed by more detailed chemical m
