729612-03-7

Upstream product

• 1357177-77-5 C₁₆H₂₉NO₄ 
• 1357177-78-6 butyl 7-[(2R)-2-(tert-butyldimethylsilyloxymethyl)-5-thioxo-1-pyrrolidinyl]heptanoate 
• 729612-09-3 butyl 7-[(2R)-2-(hydroxymethyl)-5-thioxo-1-pyrrolidinyl]heptanoate 

Relevant academic research and scientific papers

Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists

To identify chemically and metabolically stable subtype-selective EP4 agonists, design and synthesis of a series of modified γ-lactam prostanoids has been continued. Prostanoids bearing 2-oxo-1,3-oxazolidine, 2-oxo-1,3-thiazolidine and 5-thioxopyrrolidine as a surrogate for the γ-hydroxycyclopentanone without a troublesome 11-hydroxy group were identified as highly subtype-selective EP4 agonists. Among the tested, several representative compounds demonstrated in vivo efficacy after oral dosing in rats. Their pharmacokinetic and structure-activity relationship studies are presented.