72965-16-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-amino-4-isopropylthiophene-3-carboxylate is used as a therapeutic agent for the treatment of various inflammatory conditions. It is particularly effective in managing rheumatoid arthritis, osteoarthritis, and other inflammatory diseases. Ethyl 2-aMino-4-isopropylthiophene-3-carboxylate's ability to reduce inflammation and alleviate pain makes it a valuable asset in the management of these conditions.
As an Analgesic:
Ethyl 2-amino-4-isopropylthiophene-3-carboxylate is used as an analgesic to relieve pain associated with various conditions, including but not limited to musculoskeletal disorders and post-operative pain. Its pain-relieving properties are attributed to its capacity to inhibit prostaglandin synthesis, thereby reducing the perception of pain.
As an Anti-inflammatory Agent:
In the medical field, ethyl 2-amino-4-isopropylthiophene-3-carboxylate is utilized as an anti-inflammatory agent to reduce inflammation and associated symptoms. Its mechanism of action involves the inhibition of cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins that cause inflammation.
For Topical Application:
Ethyl 2-amino-4-isopropylthiophene-3-carboxylate is also used in topical formulations, providing localized relief from inflammation and pain. This mode of administration is particularly useful for conditions affecting the skin or joints, such as bursitis or tendinitis, where direct application can offer targeted relief.

Upstream product

• 868-00-8 (E,Z)-2-cyano-3,4-dimethyl-2-pentanoic acid ethyl ester 
• 563-80-4 3-methyl-butan-2-one 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 82546-84-7 2-(2-Amino-4-fluoro-phenylamino)-4-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 158460-86-7 [3-(4-Bromo-2-fluoro-benzyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-thieno[2,3-d]pyrimidin-1-yl]-acetic acid ethyl ester 
• 158460-96-9 3-(4-Bromo-2-fluoro-benzyl)-5-isopropyl-1H-thieno[2,3-d]pyrimidine-2,4-dione 
• 851853-28-6 [3-(3-fluorophenyl)-5-isopropyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylsulfanyl]acetic acid ethyl ester 
• 851852-95-4 3-(3-fluorophenyl)-5-isopropyl-2-mercapto-3H-thieno[2,3-d]pyrimidin-4-one 
• 1026693-54-8 2-[3-(4-Bromo-2-fluoro-benzyl)-ureido]-4-isopropyl-thiophene-3-carboxylic acid ethyl ester 
• 82546-89-2 2-(4-Fluoro-2-nitro-phenylamino)-4-isopropyl-thiophene-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

DNA interstrand crosslink (ICL) repair (ICLR) has been implicated in the resistance of cancer cells to ICL-inducing chemotherapeutic agents. Despite the clinical significance of ICL-inducing chemotherapy, few studies have focused on developing small-molec

Synthesis and structure of some thienopyrimidine derivatives

A series of substituted thieno[2,3-d]pyrimidines was synthesized starting from ethyl-2-amino-4-isopropylthiophene-3-carboxlate. Reaction of 2-hydrazino-5-isopropyl-thieno[2,3-d]pyrimidin-4(3H)-one and its 3-methyl analogue with different reagents afforded thieno[2,3-d]triazolo[4,3-a] pyrimidines and thieno[3,2-e]triazolo[4,3-a]pyrimidines, beside open chain derivatives.

SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS

The present invention provides novel compounds and methods useful for treating transglutaminase associated disorders such as celiac spru, Alzheimer's disease and Huntington's disease. Certain compounds of the invention are tissue transglutaminase inhibito

Structure-activity relationship study of novel tissue transglutaminase inhibitors

Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative

2-(Diethylamino)thieno[1,3]oxazin-4-ones as stable inhibitors of human leukocyte elastase

A series of 2-(diethylamino)thieno[1,3]oxazin-4-ones was synthesized and evaluated in vitro for inhibitory activity toward human leukocyte elastase (HLE). The Gewald thiophene synthesis was utilized to obtain several ethyl 2-aminothiophene-3- carboxylates. These precursors were subjected to a five-step route to obtain thieno[2,3-d][1,3]oxazin-4-ones bearing various substituents at positions 5 and 6. Both thieno[2,3-d] and thieno[3,2-d] fused oxazin-4-ones possess extraordinary chemical stability, which was expressed as rate constants of the alkaline hydrolysis. The kinetic parameters of the HLE inhibition were determined. The most potent compound, 2-(diethylamino)-4H- [1]benzothieno[2,3-d][1,3]oxazin-4-one, exhibited a K(i) value of 5.8 nM. 2-(Diethylamino)thieno[1,3]oxazin-4-ones act as acyl- enzyme inhibitors of HLE, similar to the inhibition of serine proteases by 4H-3,1-benzoxazin-4-ones. The isosteric benzene- thiophene replacement accounts for an enhanced stability of the acyl-enzyme intermediates.

Thieno pyrazine diones, their preparation and use

Novel thieno[2,3-b]pyrazine-2,3(1H,3H)-diones or tautomeric forms thereof of the formula (I) STR1 The compounds are useful in the treatment of neurological and psychiatric diseases.