72968-07-1Relevant academic research and scientific papers
Synthesis and characterization of antitumor-active platinum 2,2-dimethyl- 1,3-diaminopropane compounds. Crystal and molecular structure of (malonato)(2,2-dimethyl-1,3-diaminopropane)platinum(II)
Van Kralingen, Cornelis G.,Reedijk, Jan,Spek, Anthony L.
, p. 1481 - 1485 (2008/10/08)
The synthesis and characterization of a series of platinum compounds containing 2,2-dimethyl-1,3-diaminopropane (DMDAP) are described. The compounds are Pt(DMDAP)X2 with X2 = Cl2, Br2, I2, or malonate and Pt(DMDAP)Cl4. The crystal structure of the malonate compound has been determined from three-dimensional single-crystal X-ray data. The complex crystallizes in space group P21/m of the monoclinic system with two formula units in a unit cell of dimensions a = 5.807 (2) ?, b = 9.980 (5) ?, c = 9.667 (2) ?, and β = 96.31 (3)°. The structure was solved by standard Patterson and Fourier methods and refined by full-matrix least-squares techniques to a value of the conventional RF factor of 0.021 (RwF = 0.034) by using 1260 observed reflections. The molecule lies on a crystallographic mirror plane passing through the platinum atom, the methylene group of the malonate ion, and the C(CH3)2 group of the amine. The coordination geometry around Pt is square planar with two oxygen atoms at 2.029 (4) ? and two nitrogen atoms at 2.022 (4) ?. The N-Pt-N angle is 97.2 (2)°, and the O-Pt-O angle is 90.1 (2)°. The crystal structure consists of layers perpendicular to the c axis in which the molecules are pseudohexagonally stacked and coupled through hydrogen bonds of the type N-H?O. The Pt-amine chelate ring adopts a chair conformation strongly flattened at the PtN2 end while the Pt-malonate chelate ring has a boat conformation. The chloro compounds and the malonate compound show significant activity against the L-1210 leukemia in mice. Some remarks concerning the relation between structure and activity of the platinum compounds are made.
