72975-49-6

Usage

Uses

Used in Pharmaceutical Synthesis:
Pyrimidine, 2-isocyanato(9CI) is used as a key intermediate in the synthesis of pharmaceuticals for its ability to react with nucleophiles, facilitating the creation of a wide range of medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, Pyrimidine, 2-isocyanato(9CI) serves as a precursor to various agrochemicals, contributing to the development of effective products for crop protection and enhancement.
Used in Specialty Chemicals Manufacturing:
Pyrimidine, 2-isocyanato(9CI) is utilized in the production of specialty chemicals, where its unique reactivity allows for the synthesis of specific compounds tailored for particular applications.
Used in Polymer Production:
Pyrimidine, 2-isocyanato(9CI) also finds application in the polymer industry, where it can be incorporated into the polymer backbone to impart specific properties or functions to the final polymer product.
Used as a Precursor to Other Organic Compounds:
Pyrimidine, 2-isocyanato(9CI) is used as a precursor in the synthesis of other organic compounds, highlighting its importance in organic chemistry and its potential for creating diverse chemical entities.
It is crucial to handle Pyrimidine, 2-isocyanato(9CI) with care due to its potential toxicity and harmful effects if not used properly, emphasizing the need for safety measures in its application and manipulation.

InChI:InChI=1/C5H3N3O/c9-4-8-5-6-2-1-3-7-5/h1-3H

Upstream product

• 1174538-74-9 C₅H₃N₅O 
• 109-12-6 2-aminopyrimidine 
• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant academic research and scientific papers

Electrochemical Synthesis of Imidazo-Fused N-Heteroaromatic Compounds through a C?N Bond-Forming Radical Cascade

We have developed a unified strategy for preparing a variety of imidazo-fused N-heteroaromatic compounds through regiospecific electrochemical (3+2) annulation reaction of heteroarylamines with tethered internal alkynes. The electrosynthesis employs a novel tetraarylhydrazine as the catalyst, has a broad substrate scope, and obviates the need for transition-metal catalysts and oxidizing reagents.

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): Potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts

The development of CDK and GSK3 inhibitors has been regarded as a potential therapeutic approach, and a substantial number of diverse structures have been reported to inhibit CDKs and GSK-3β in recent years. Only a few molecules have gone through or are currently undergoing clinical trials as CDK and GSK inhibitors. In this paper, we prepared valmerins, a new family containing the tetrahydropyrido[1,2-a]isoindone core. The fused heterocycle was prepared with a straightforward synthesis that was functionalized by a (het)arylurea. Twelve valmerins inhibited the CDK5 and GSK3 with an IC50 100 nM. A semiquantitative kinase scoring was realized, and a cellular screening was done. At the end of our study, we investigated the in vivo potency of one valmerin. Mice exhibited good tolerance to our lead, which proved its efficacy and clearly blocked tumor growth. Valmerins appear also as good candidates for further development as anticancer agents.