72996-73-7

Usage

Uses

Used in Pharmaceutical Industry:
4-(Methoxymethyl)-N-phenyl-1-<2-(2-thienyl)ethyl>-4-piperidinamine is used as an impurity in the production of Sufentanil (S699040), a potent analgesic (narcotic) and a controlled substance (opiate). Its presence in the manufacturing process may affect the purity and efficacy of the final product.

Upstream product

• 74-88-4 methyl iodide 
• 61380-07-2 2-(thiophen-2-yl)ethyl methanesulfonate 
• 62-53-3 aniline 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1159835-31-0 1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid 
• 5402-55-1 2-thiophenethanol 

Relevant academic research and scientific papers

Preparation method of alfentanil and sufentan and compounds used for preparation of sufentanil and alfentan

The invention discloses a preparation method of alfentanil and sufentan and compounds used for preparation of sufentanil and alfentan. Specifically, the method for preparation of a compound shown as formula V includes: carrying out BOC reaction on a compound shown as formula IV to obtain the compound shown as formula V in the specification. The method can conveniently, efficiently and safely prepare an intermediate product for synthesis of alfentanil and sufentan, i.e. the compound shown as formula V. And then, the compound shown as formula V can be effectively used for preparation of alfentanil and sufentan.

Process for the Preparation of Sufentanil Base and Related Compounds

The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which