73008-34-1Relevant articles and documents
Design, synthesis and biological evaluation of novel hydroxy-phenyl-1H-benzimidazoles as radical scavengers and UV-protective agents
Bino, Alessia,Baldisserotto, Anna,Scalambra, Emanuela,Dissette, Valeria,Vedaldi, Daniela Ester,Salvador, Alessia,Durini, Elisa,Manfredini, Stefano,Vertuani, Silvia
, p. 527 - 537 (2017)
An ever-increasing incidence of skin neoplastic diseases is registered. Therefore, it is important to protect the skin from the UV radiation that reaches the epidermis and dermis but also to block ROS generated by them. Our attention was attracted in deve
Synthesis of novel benzimidazoles at room temperature, under solvent-free condition and their biological studies
Gulati, Susheel,Singh, Rajvir,Sangwan, Suman,Rana, Suprita
, p. 167 - 179 (2020/08/05)
Abstract: An efficient and facile synthesis of substituted novel benzimidazoles (3a–3h) mediated by fruit juices viz. Cocos nucifera L. juice, Citrus limetta juice and Citrus sinensis L. juice, via condensation of substituted aldehydes (1a–1h) and o-pheny
Exploring beta amyloid cleavage enzyme-1 inhibition and neuroprotective role of benzimidazole analogues as anti-alzheimer agents
Gurjar, Archana S.,Solanki, Vivek S.,Meshram, Ankita R.,Vishwakarma, Suchita S.
, p. 864 - 873 (2019/11/14)
Beta amyloid cleavage enzyme-1 (BACE1) is the key enzyme involved in Aβ peptide formation in Alzheimer's disease pathogenesis. We intend to target this enzyme by exploring benzimidazole analogues against BACE1 as potential anti-Alzheimer agents. Docking studies were performed to determine the hydrogen bond interactions between the designed molecules and the target protein's active site. Research indicates the relationship between oxidative stress and Aβ effect in precipitating neurodegeneration; hence, the series was also studied in vitro to ascertain its neuroprotective role by performing the lipid peroxidation assay. In silico absorption, distribution, metabolism, and excretion studies were undertaken to assess the drug-like suitability of the analogues. To judge the effect of the synthesized analogues on central nervous system (CNS), toxicity and memory model studies were conducted on mice. Thus, overall results showcase analogues 11 and 14 as the most promising ones with the dual role of BACE1 inhibition and neuroprotection, along with memory retention.
