7301-63-5Relevant academic research and scientific papers
Electrochemical Regioselective Phosphorylation of Nitrogen-Containing Heterocycles and Related Derivatives
Deng, Yong,You, Shiqi,Ruan, Mengyao,Wang, Ying,Chen, Zuxing,Yang, Guichun,Gao, Meng
, p. 464 - 469 (2021)
The site-selective functionalization of biologically important nitrogen-containing heterocycles and related derivatives remains a challenging and important task. We report herein on the direct regiodivergent N1/C2 phosphorylation of free indole derivatives. Cyclic voltammograms and EPR data indicate that by utilizing different electrolyte-mediated anodic oxidation to generate different active indole species, a diverse collection of N1 and C2 phosphorylation products could be obtained in moderate to high yields under exogenous-oxidant-free and metal-catalyst-free electrochemical conditions. In addition, N?P coupling was also found to be compatible with various alkylamines. (Figure presented.).
