73011-32-2

Upstream product

• 824-91-9 O-methoxymethylphenol 
• 533-58-4 2-Iodophenol 
• 95-56-7 2-hydroxybromobenzene 
• 717106-98-4 2-methoxymethoxy-benzeneselenol 
• 717106-99-5 bis[(2-methoxymethyloxy)phenyl]diselenide 

Downstream Products

• 1361315-57-2 (2R,2′R)-dimethyl 2,2′-[diselenobis(2,1-phenyleneoxy)]bispropionate 
• 1361315-54-9 diethyl (2R,2'R)-2,2'-[diselane-1,2-diylbis(2,1-phenyleneoxy)]dipropanoate 
• 1361315-55-0 diisopropyl (2R,2'R)-2,2'-[diselane-1,2-diylbis(2,1-phenyleneoxy)]dipropanoate 
• 1361315-59-4 isopropyl (2R)-2-(2-((2-methoxy-2-phenylethyl)selanyl)phenoxy)propanoate 
• 1361315-56-1 dimethyl (2R,2'R)-2,2'-[diselane-1,2-diylbis(2,1-phenyleneoxy)]bis(3-methylbutanoate) 
• 1361315-60-7 methyl (2R)-2-(2-((2-methoxy-2-phenylethyl)selanyl)phenoxy)-3-methylbutanoate 
• 1361315-58-3 ethyl (2R)-2-{2-[(2-methoxy-2-phenylethyl)seleno]phenoxy}propanoate 
• 1361315-61-8 methyl (2R)-2-(2-((2-methoxy-2-phenylethyl)selanyl)phenoxy)propanoate 
• 1361315-62-9 ethyl (2R)-2-(2-{[2-(2-chlorophenyl)-2-methoxyethyl]selanyl}phenoxy)propanoate 
• 1361315-63-0 ethyl (2R)-2-(2-{[2-methoxy-2-(m-tolyl)ethyl]selanyl}phenoxy)propanoate 

Relevant academic research and scientific papers

An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides

A target synthesis of a library of symmetric aromatic diselenides was attempted with the aim of generating anticancer lead compounds. Out of thirteen screened molecules (1-13) against a panel of human cancer cell lines, compound 8 exhibited highest cell growth inhibition in Human leukemia HL-60 cells with IC50 value of 8 μM. Compound 8 had a good pro-apoptotic potential as evidenced from several apoptotic protocols like DNA cell cycle analysis and monitoring of apoptotic bodies formation using phase contrast and nuclear microscopy with Hoechst 33,258. Also, 8 significantly inhibits S phase of the cell cycle and eventually trigger apoptosis in HL-60 cells through mitochondrial dependent pathway substantiated by the loss of mitochondrial potential. A theoretical investigation of DNA binding ability of 8 showed that it selectively bind to minor groove of DNA, where it is stabilized by hydrogen bonding and hydrophobic interactions.

Asymmetric methoxyselenenylations with chiral selenium electrophiles

Very simple, chiral, non-racemic diselenides were prepared and their corresponding selenium electrophiles were used for the stereoselective functionalization of alkenes. The influence of different alkenes on the outcome of the selenenylation reaction was

An efficient one-pot synthesis of symmetrical diselenides or ditellurides from halides with CuO nanopowder/Se0 or Te0/base

(Equation Presented). A CuO nanopowder-catalyzed coupling reaction of aryl, alkyl, and heteroaryl iodides with elemental selenium and tellurium takes place in the presence of KOH at 90 °C in DMSO. A wide range of substituted symmetrical diselenides and ditellurides were afforded with good to excellent yields.

Synthesis of novel organoselenium as catalyst for Baeyer-Villiger oxidation with 30% H2O2

A novel diselenide was synthesized in good yield via only four steps from phenol, and was employed as the catalyst for the Baeyer-Villiger oxidation with 30% H2O2 to obtain lactones in good yields.

Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: Synthesis and properties

The different dialkyl and diaryl diselenides with carbamoyl and sulfamoyl moieties 2, 3, 5 and other substituents in the ortho position of benzene ring 4, 7, 8 as well as derivatives of 1,2,4-benzoselenadiazine (6) were designed as antiviral and antimicrobial agents and synthesized. Some of them, particularly 8a and 8b, were found in the antiviral assay in vitro to be strong inhibitors of cytopathic activity encephalomyocarditis virus (EMCV). The compound 4a and 8a were found to have a broad spectrum of acivity against bacteria, yeasts and pathogenic fungi in vitro.