73025-03-3Relevant academic research and scientific papers
The anticonvulsant and CNS activity of N-butyryl-N-butylurea in mice
Dar,Zirvi,Fakouhi
, p. 936 - 944 (2007/10/14)
As a further extension of the authors' studies related to CNS activity of substituted butylureas, a number of derivatives of butylurea were synthesized. Among these a derivative of n-butylurea, N-butyryl-N-butylurea (NBNB) was prepared by acylation of n-butylurea with butyryl chloride in pyridine. The compound was found to possess considerable sedative-hypnotic action. Sleeping time of pentobarbital and barbital was significantly potentiated by NBNB. The compound also exhibited moderate anti-tremorine action and produced significant reduction in the activity ratio for Treadmill experiments. Significant anticonvulsive activity of NBNB was observed against strychnine, pentetrazole and supramaximal electroshock-induced convulsions. In addition to projection against tonic convulsions, the animals were also protected against strychnine and pentetrazole lethality.
