73027-64-2Relevant academic research and scientific papers
One-pot syntheses of 5-amino-1-aryltetrazole derivatives
Vorobiov, Andrey N.,Gaponik, Pavel N.,Petrov, Petr T.,Ivashkevich, Oleg A.
, p. 1307 - 1312 (2007/10/03)
A novel facile route for the introduction of 5-amino and 5-alkylamino substituents into 1-aryltetrazoles has been developed. A range of 5-amino-1-aryltetrazoles was obtained directly from the corresponding 1-aryltetrazoles in one pot by consecutive ring-opening, azidation and intramolecular cyclization. 5-Alkylamino-1-aryltetrazoles were formed by a similar mechanism from 1,4-disubstituted tetrazolium salts. An influence of the nature of aryl substituents and reaction conditions on the regioselectivity of the intramolecular cyclization of intermediate guanyl azides is revealed. Georg Thieme Verlag Stuttgart.
