73027-67-5Relevant academic research and scientific papers
Sequential Pd(0)/Fe(III) Catalyzed Azide-Isocyanide Coupling/Cyclization Reaction: One-Pot Synthesis of Aminotetrazoles
Pathare, Ramdas S.,Ansari, Arshad J.,Verma, Sarika,Maurya, Anand,Maurya, Antim K.,Agnihotri, Vijai K.,Sharon, Ashoke,Pardasani, Ram T.,Sawant, Devesh M.
, p. 9530 - 9537 (2018)
A rapid and efficient synthesis of aminotetrazole from aryl azides, isocyanides, and TMSN3 is developed. The reaction is promoted by sequential Pd(0)/Fe(III) catalysis. The reaction sequence utilizes the Pd-catalyzed azide-isocyanide denitrogenative coupling reaction to generate unsymmetric carbodiimide in situ, which reacts with TMSN3 in the presence of FeCl3 in a single pot. The methodology has distinct advantages over traditional synthetic approaches where toxic Hg and Pb salts are employed at stoichiometric scale.
