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2,4-bis-(4-methoxy-benzyloxy)-pyrimidine is a complex organic compound with the molecular formula C18H20N2O6. It is characterized by a pyrimidine core, which is a heterocyclic aromatic organic compound consisting of a six-membered ring with four carbon atoms and two nitrogen atoms. The compound features two 4-methoxy-benzyloxy substituents attached to the 2nd and 4th positions of the pyrimidine ring. Each of these substituents consists of a benzyloxy group (a benzyl alcohol derivative) with a methoxy group (-OCH3) attached to the para position (4th position) of the benzene ring. This chemical structure endows the compound with specific properties that may be relevant in various chemical and pharmaceutical applications, such as the synthesis of more complex molecules or as intermediates in the production of certain drugs.

7306-80-1

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7306-80-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7306-80-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,0 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7306-80:
(6*7)+(5*3)+(4*0)+(3*6)+(2*8)+(1*0)=91
91 % 10 = 1
So 7306-80-1 is a valid CAS Registry Number.

7306-80-1Downstream Products

7306-80-1Relevant academic research and scientific papers

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif

Filipski, Kevin J.,Guzman-Perez, Angel,Bian, Jianwei,Perreault, Christian,Aspnes, Gary E.,Didiuk, Mary T.,Dow, Robert L.,Hank, Richard F.,Jones, Christopher S.,Maguire, Robert J.,Tu, Meihua,Zeng, Dongxiang,Liu, Shenping,Knafels, John D.,Litchfield, John,Atkinson, Karen,Derksen, David R.,Bourbonais, Francis,Gajiwala, Ketan S.,Hickey, Michael,Johnson, Theodore O.,Humphries, Paul S.,Pfefferkorn, Jeffrey A.

, p. 4571 - 4578 (2013/08/15)

Glucokinase activators are a class of experimental agents under investigation as a therapy for Type 2 diabetes mellitus. An X-ray crystal structure of a modestly potent agent revealed the potential to substitute the common heterocyclic amide donor-acceptor motif for a pyridone moiety. We have successfully demonstrated that both pyridone and pyrimidone heterocycles can be used as a potent donor-acceptor substituent. Several sub-micromolar analogs that possess the desired partial activator profile were synthesized and characterized. Unfortunately, the most potent activators suffered from sub-optimal pharmacokinetic properties. Nonetheless, these donor-acceptor motifs may find utility in other glucokinase activator series or beyond.

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