Welcome to LookChem.com Sign In|Join Free

CAS

  • or

73069-13-3

Post Buying Request

73069-13-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 100%natural Atractylodes Extract,Manufacturer Atractylodes Extract,Manufacturer Supply High Quality Atractylodes Extract CAS NO.73069-13-3

    Cas No: 73069-13-3

  • USD $ 1.0-3.0 / Metric Ton

  • 1 Metric Ton

  • 10 Metric Ton/Day

  • Hebei yanxi chemical co.,LTD.
  • Contact Supplier

73069-13-3 Usage

Description

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

Check Digit Verification of cas no

The CAS Registry Mumber 73069-13-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,0,6 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 73069-13:
(7*7)+(6*3)+(5*0)+(4*6)+(3*9)+(2*1)+(1*3)=123
123 % 10 = 3
So 73069-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1

73069-13-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Atractylenolide I

1.2 Other means of identification

Product number -
Other names Atractylenolide-1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73069-13-3 SDS

73069-13-3Upstream product

73069-13-3Relevant articles and documents

Dimerization of butenolide structures. A biomimetic approach to the dimeric sesquiterpene lactones (±)-biatractylolide and (±)- biepiasterolide

Bagal, Sharanjeet K.,Adlington, Robert M.,Baldwin, Jack E.,Marquez, Rodolfo

, p. 9100 - 9108 (2007/10/03)

The biomimetic synthesis of the bisesquiterpene lactones (±)-biatractylolide 1 and (±)-biepiasterolide 2 via dimerization of the captodative stabilized radical 8 is reported. Atractylon 7 has also been shown to be a possible intermediate during the biosynthesis of biatractylolide 1, biepiasterolide 2, atractylolide 3, and hydroxyatractylolide 4.

Terpenes and Terpene Derivatives, XIII. - Synthesis of (+/-)-8,9-Dehydroasterolide

Bokel, Heinz-Hermann,Marschall, Helga,Weyerstahl, Peter

, p. 73 - 79 (2007/10/02)

From the ketoester 2 the α,β-unsaturated ketone 9 is prepared via ketalization (--> 3), hydroboration (--> 4), oxidation (--> 6), Wittig reaction (--> 7), hydrolysis (--> 8a), and oxidative decarboxylation. 9 is a useful starting material for the synthesis of 8,9-dehydroasterolide (1) via epoxidation (--> 10), PO olefination (--> 11), hydrolysis (--> 12), and dehydratization.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 73069-13-3