73083-05-3

Basic information

• Product Name: 2(1H)-Isoquinolinecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-, ethyl ester
• CAS NO: 73083-05-3
• Molecular Formula: C22H27NO6
• Molecular Weight: 401.459
• Mol File: 73083-05-3.mol

Chemical Properties

• CAS DataBase Reference: 2(1H)-Isoquinolinecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Isoquinolinecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-, ethyl ester(73083-05-3)
• EPA Substance Registry System: 2(1H)-Isoquinolinecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-, ethyl ester(73083-05-3)

Safety Data

• Hazardous Substances Data: 73083-05-3(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 541-41-3 chloroformic acid ethyl ester 
• 17889-63-3 N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Relevant articles and documents

One-pot α-amidosulfone-mediated variation of the pictet-Spengler tetrahydroisoquinoline synthesis, suitable for amide-type substrates

The development of Pictet-Spengler reactions from amide substrates is a challenging problem. We report here that the reaction between amide-type compounds (including carbamates, amides, ureas and diketopiperazines), aldehydes and p-toluenesulfinic acid constitutes an efficient method for the preparation of tetrahydroisoquinolines or pyrazino-[2,1-b]isoquinolines. Unlike previously known methods, this one-pot Pictet-Spengler protocol avoids the need for strong Lewis or Br?nsted acid catalysts.

Synthesis of 1-aryl-2-acyltetrahydroisoquinolines with an electron withdrawing group in the aromatic ring of heterocycle

The intermolecular α-amidoalkylation reaction of adducts 3 obtained from acyl chlorides and 3,4-dihydroisoquinoline with an electron withdrawing group in the aromatic ring such as 7-nitro-3,4-dihydroisoquinoline towards aromatics has been investigated.