73086-04-1Relevant academic research and scientific papers
Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities
Suda, Manato,Katoh, Miyuki,Toda, Kazuya,Matsumoto, Kiriko,Kawaguchi, Koichiro,Kawahara, Sei-Ichi,Hattori, Yasunao,Fujii, Hiroshi,Makabe, Hidefumi
supporting information, p. 4935 - 4939 (2013/09/02)
Synthesis of procyanidin B2 and B3 gallate derivatives, 3-O-gallate, 3″-O-gallate, and 3,3″-di-O-gallate, were synthesized using equimolar condensation mediated by Yb(OTf)3. Synthesized compounds showed significant antitumor effects against human prostate PC-3 cell lines. Their activities were weaker than well-known EGCG and prodelphinidin B3.
Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases
Saito, Akiko,Mizushina, Yoshiyuki,Ikawa, Hiroshi,Yoshida, Hiromi,Doi, Yuki,Tanaka, Akira,Nakajima, Noriyuki
, p. 2759 - 2771 (2007/10/03)
Six galloyl-substituted procyanidin B1 and B2, 3-O-gallate, 3″-O-gallate, and 3,3″-di-O-gallate, were systematically synthesized with the condensation method using TMSOTf as a catalyst. Their ability of DPPH radical scavenging activity and DNA polymerase inhibitory activity were also investigated. The results indicated that the galloyl group of these compounds is very important for both activities. 3,3″-Di-O-gallate dimers acted as strong inhibitor against DNA polymerase α and β, whereas the desgalloyl and monogalloyl compounds did not exhibit any appreciable inhibitory activity against the DNA polymerase β.
