73089-93-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Hydroxyethyl)cyclopentanol is used as a solvent and intermediate in the synthesis of pharmaceuticals for its ability to dissolve a wide range of compounds and facilitate chemical reactions.
Used in Cosmetics Industry:
1-(2-Hydroxyethyl)cyclopentanol is used as a building block for the synthesis of other compounds in cosmetics, contributing to the formulation of various cosmetic products due to its mild properties and compatibility with other ingredients.
Used in Flavors Industry:
1-(2-Hydroxyethyl)cyclopentanol is used as a component in the creation of flavors, leveraging its mild odor and ability to blend with other compounds to produce desired taste profiles.
Safety Considerations:
It is important to handle 1-(2-Hydroxyethyl)cyclopentanol with caution, as prolonged or excessive exposure to it may cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be taken during its use in various applications.

Upstream product

• 7499-04-9 2-(1-hydroxycyclopentyl)acetic acid 
• 57-57-8 β-Propiolactone 
• 23708-47-6 1,4-bis(bromomagnesium)butane 
• 3197-76-0 ethyl 2-(1-hydroxycyclopentyl)acetate 
• 120-92-3 cyclopentanone 
• 110-52-1 1,4-dibromo-butane 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 13278-09-6 tert-butyl 2-(1-hydroxycyclopentyl)acetate 
• 190381-00-1 1-[2'-(allyldimethylsilyl)ethyl]cyclopentan-1-ol 

Downstream Products

• 114694-22-3 2-(1-hydroxycyclopentyl)ethyl 4-methylbenzenesulfonate 
• 1140918-74-6 N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-[2-(1-hydroxycyclopentyl)ethoxy]-5-(trifluoromethyl)benzamide 
• 1369331-43-0 C₁₄H₁₈O 
• 1369331-34-9 C₂₁H₂₅ClO₂S 
• 114694-26-7 (1R,3aS,7aR)-1-[(R)-3-Benzenesulfonyl-1-methyl-4-(1-triethylsilanyloxy-cyclopentyl)-butyl]-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene 
• 114694-28-9 (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-1-[(R)-1-methyl-4-(1-triethylsilanyloxy-cyclopentyl)-butyl]-octahydro-indene 
• 114694-10-9 26,27-trimethylene-1,25-dihydroxyvitamin D₃ 
• 114694-25-6 1-<2-(phenylsulfonyl)ethyl>-1-<(triethylsilyl)oxy>cyclopentane 
• 114694-24-5 1-(2-Benzenesulfonyl-ethyl)-cyclopentanol 
• 114694-23-4 1-(2-Phenylsulfanyl-ethyl)-cyclopentanol 
• 3197-73-7 2-(cyclopent-1-en-1-yl)ethanol 
• 120-92-3 cyclopentanone 

Relevant academic research and scientific papers

Synthesis and Biological Activity of 2,22-Dimethylene Analogues of 19-Norcalcitriol and Related Compounds

Continuing our search for Vitamin D analogues, we explored the modification of the steroidal side chain and inserted a methylene moiety in position C-22 together with either lengthening the side chain or introducing a ring at the terminal end. Our conform

IMMUNOPROTEASOME INHIBITORS

Provided herein are compounds, such as a compound of Formula (I), or a pharmaceutically acceptable salt thereof, that are immunoproteasome (such as LMP2 and LMP7) inhibitors. The compounds described herein can be useful for the treatment of diseases treatable by inhibition of immunoproteasomes. Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

A new approach to the synthesis of 1-oxaspiro[4.n]alkanes and tetrahydrofurans by the 1,5-CH insertion reaction of magnesium carbenoids

1-Alkoxy-1-[2-chloro-2-(p-tolylsulfinyl)ethyl]cycloalkanes were prepared from various cyclic ketones in good overall yields. Treatment of these cycloalkanes bearing a sulfinyl group with i-PrMgCl resulted in the formation of 1-oxaspiro[4.n]alkanes in high to quantitative yields via the 1,5-CH insertion reaction of generated magnesium carbenoid intermediates. When this procedure was commenced with acyclic ketones, multi-substituted tetrahydrofurans were obtained in up to a 96% yield. This procedure provides a new and good way for the synthesis of 1-oxaspiro[4.n]alkanes and tetrahydrofurans with the formation of a carbon-carbon bond between a carbenoid carbon and a non-activated carbon in high yields. The oxygen atom in the magnesium carbenoid intermediates was proved to act very important roles in the 1,5-CH insertion reaction.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Cyclic Ether Formation in Superacid Media

The formation of ethers in superacids by interaction of a primary hydroxy group with a carbocation centre has been investigated by a study of cyclisation of suitable substrates, mainly 1-(2-hydroxyethyl)cyclohexanols to give hydrobenzofurans.Cyclisation traps thermodynamically stable ionic species, with rates of reaction dependent upon the size of the ether ring formed.Three- and four-membered ether rings were not formed, five-membered ether rings formed readily, the reaction being comparable in rate with a 1,2-methyl shift.Six-membered rings formed a little less readily and seven-membered rings less readily still, though a yield of 34 percent from a suitable substrate has been recorded.An unexpected feature of the reactions was their stereospecificity; in one case, this is believed to result from a methyl shift concerted with attack of the primary hydroxy group, the reaction proceeding through hindered transition state, in which methyl loss, probably as CH3+, competes with a 1,2-methyl shift.