730992-72-0Relevant academic research and scientific papers
A New, Short, and Stereocontrolled Synthesis of C2-Symmetric 1,2-Diamines
Vemula, Rajender,Wilde, Nathan C.,Goreti, Rajendar,Corey
, p. 3883 - 3886 (2017/07/26)
The previously unknown 5-spirocyclohexylisoimidazole has been made efficiently and simply by reaction of ammonia, glyoxal hydrate, and cyclohexanone. It is a very useful precursor for the diastereocontrolled synthesis of many C2-symmetric 1,2-diamines, a class which is important for the generation of a variety of C2-symmetric reagents and catalysts for enantioselective synthesis.
Synthesis of enantiomerically pure (R,R)- and (S,S)-1,2-Bis(pentafluorophenyl)ethane-1,2-diamine and evaluation of the pK a value by ab initio calculations
Sakai, Takashi,Korenaga, Toshinobu,Washio, Noriyuki,Nishio, Yuji,Minami, Shinichi,Ema, Tadashi
, p. 1001 - 1008 (2007/10/03)
1,2-Bis(pentafluorophenyl)ethane-1,2-diamine (1) was synthesized by the imino pinacol coupling of 4-methoxy-N-(pentafluorobenzylidene)benzylamine using a Zn-Cu couple and p-TsOH·H2O. The optical resolution of (±)-1 by means of chiral HPLC gave
